Research News

A Comparative Study of Single and Dual Perfusion During End-ischemic Subnormothermic Liver Machine Preservation

Dec 12 2018

Author(s): Isabel M A Brüggenwirth,Carolina Moore,Paria Mahboub,Max F Thijssen,Xiaofei E,Henri G D Leuvenink,Pranoti Mandrekar,Xiaofei Wang,Timothy F Kowalik,Robert J Porte,Paulo N Martins

Source: Transplantation direct

CONCLUSIONS: This study shows comparable outcomes after using a dual or single perfusion approach during end-ischemic subnormothermic liver machine preservation.

Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing

Dec 12 2018

Author(s): Mehmet Fatih Bolukbasi,Pengpeng Liu,Kevin Luk,Samantha F Kwok,Ankit Gupta,Nadia Amrani,Erik J Sontheimer,Lihua Julie Zhu,Scot A Wolfe

Source: Nature communications

The original version of this Article contained errors in the author affiliations. Mehmet Fatih Bolukbasi was incorrectly associated with Bluebird Bio., Cambridge, MA, USA and Ankit Gupta was incorrect...

Vestibular Traumatic Neuroma Following Temporal Bone Fracture

Dec 12 2018

Author(s): Renata M Knoll,Danielle R Trakimas,Reuven Ishai,Anat Stemmer-Rachamimov,Aaron K Remenschneider,Joseph B Nadol,David H Jung,Elliott D Kozin

Source: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

No abstract

Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering

Dec 07 2018

Author(s): Hannah A Strobel,Elisabet I Qendro,Eben Alsberg,Marsha W Rolle

Source: Frontiers in pharmacology

Cardiovascular diseases are the leading cause of death in the United States. Treatment often requires surgical interventions to re-open occluded vessels, bypass severe occlusions, or stabilize aneurys...

Enhancement of Declarative Memory: From Genetic Regulation to Non-invasive Stimulation

Nov 27 2018

Author(s): D V Bryzgalov,I L Kuznetsova,E I Rogaev

Source: Biochemistry. Biokhimiia

The problem of memory enhancement is extremely important in intellectual activity areas and therapy of different types of dementia, including Alzheimer's disease (AD). The attempts to solve this probl...

Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class II

Nov 27 2018

Author(s): M P Aliseychik,T V Andreeva,E I Rogaev

Source: Biochemistry. Biokhimiia

An increase in the life expectancy during the last decades in most world countries has resulted in the growing number of people suffering from neurodegenerative disorders, including Alzheimer's diseas...

Genetic Association between Alzheimer's Disease Risk Variant of the PICALM Gene and Auditory Event-Related Potentials in Aging

Nov 27 2018

Author(s): N V Ponomareva,T V Andreeva,M A Protasova,Yu V Filippova,E P Kolesnikova,V F Fokin,S N Illarioshkin,E I Rogaev

Source: Biochemistry. Biokhimiia

Aging and genetic predisposition are major risk factors in age-related neurodegenerative disorders. The most common neurodegenerative disorder is Alzheimer's disease (AD). Genome-wide association stud...

Different Pathways to Neurodegeneration

Nov 27 2018

Author(s): E I Rogaev

Source: Biochemistry. Biokhimiia

The current issue is dedicated to the studies of neurodegenerative diseases and memory. Molecular mechanisms and mutant genes have already been revealed for many neurodegenerative diseases. However, i...

Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior

Oct 18 2018

Author(s): Sukhee Cho,Allie K Muthukumar,Tobias Stork,Jaeda C Coutinho-Budd,Marc R Freeman

Source: Proceedings of the National Academy of Sciences of the United States of America

Astrocytes are important regulators of neural circuit function and behavior in the healthy and diseased nervous system. We screened for molecules in Drosophila astrocytes that modulate neuronal hypere...

Sequential aneurysms of the internal carotid artery with fibromuscular dysplasia

Sep 25 2018

Author(s): Eric Bluemn,Calvin Chao,Andres Schanzer

Source: Journal of vascular surgery

No abstract

Commonly Initiated Opioids and Risk of Fracture Hospitalizations in United States Nursing Homes

Sep 07 2018

Author(s): Jacob N Hunnicutt,Anne L Hume,Shao-Hsien Liu,Christine M Ulbricht,Jennifer Tjia,Kate L Lapane

Source: Drugs & aging

CONCLUSIONS: The lower rate of fractures that we documented among tramadol initiators compared with hydrocodone initiators is consistent, albeit attenuated compared with prior studies among community-...

Intuitive versus Algorithmic Triage

Aug 22 2018

Author(s): Alexander Hart,Elias Nammour,Virginia Mangolds,John Broach

Source: Prehospital and disaster medicine

CONCLUSION: Significant time may be saved using the intuitive triage method. Comparing START and intuitive triage groups, there was a very high degree of agreement between triage categories. More pros...

Predictive utility of an emergency department decision support tool in patients with active suicidal ideation

Aug 07 2018

Author(s): Edwin D Boudreaux,Celine Larkin,Nisha Kini,Lisa Capoccia,Michael H Allen,Julie Goldstein Grumet,Morton M Silverman,Richard McKeon,Bruce Barton,Ivan Miller,Scott W Formica,Carlos A Camargo

Source: Psychological services

Emergency department (ED) clinicians routinely decide the disposition of patients with suicidal ideation, with potential consequences for patient safety, liability, and system costs and resources. An ...

Competence in Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography, From Training Through Independent Practice

Jul 30 2018

Author(s): Sachin Wani,Rajesh N Keswani,Samuel Han,Eva M Aagaard,Matthew Hall,Violette Simon,Wasif M Abidi,Subhas Banerjee,Todd H Baron,Michael Bartel,Erik Bowman,Brian C Brauer,Jonathan M Buscaglia,Linda Carlin...

Source: Gastroenterology

CONCLUSIONS: In this prospective multicenter study, we found that although competence cannot be confirmed for all AETs at the end of training, most meet QI thresholds for EUS and ERCP at the end of th...

A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A

Jul 18 2018

Author(s): Sultan Ciftci-Yilmaz,Wei-Chun Au,Prashant K Mishra,Jessica R Eisenstatt,Joy Chang,Anthony R Dawson,Iris Zhu,Mahfuzur Rahman,Sven Bilke,Michael Costanzo,Anastasia Baryshnikova,Chad L Myers,Paul S Meltz...

Source: Genetics

Centromeric localization of the evolutionarily conserved centromere-specific histone H3 variant CENP-A (Cse4 in yeast) is essential for faithful chromosome segregation. Overexpression and mislocalizat...

Postpartum Hospital Utilization among Massachusetts Women with Intellectual and Developmental Disabilities: A Retrospective Cohort Study

Jun 28 2018

Author(s): Monika Mitra,Susan L Parish,Ilhom Akobirshoev,Eliana Rosenthal,Tiffany A Moore Simas

Source: Maternal and child health journal

Objectives This study examined the risk of postpartum hospital admissions and emergency department (ED) visits among US women with intellectual and developmental disabilities (IDD). Methods We used th...

Association of religiosity and spirituality with quality of life in patients with cardiovascular disease: a systematic review

Jun 28 2018

Author(s): Hawa O Abu,Christine Ulbricht,Eric Ding,Jeroan J Allison,Elena Salmoirago-Blotcher,Robert J Goldberg,Catarina I Kiefe

Source: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

CONCLUSIONS: Our findings suggest that higher levels of R/S may be related to better QOL among patients with CVD, with varying associations depending on the R/S dimension and QOL domain assessed. Futu...

Computer design of microfluidic mixers for protein/RNA folding studies

Jun 21 2018

Author(s): Venkatesh Inguva,Sagar V Kathuria,Osman Bilsel,Blair James Perot

Source: PloS one

Kinetic studies of biological macromolecules increasingly use microfluidic mixers to initiate and monitor reaction progress. A motivation for using microfluidic mixers is to reduce sample consumption ...

Efficacy and safety of direct oral anticoagulants approved for cardiovascular indications: Systematic review and meta-analysis

May 26 2018

Author(s): Raghavendra Charan P Makam,David C Hoaglin,David D McManus,Victoria Wang,Joel M Gore,Frederick A Spencer,Richeek Pradhan,Hoang Tran,Hong Yu,Robert J Goldberg

Source: PloS one

CONCLUSIONS: Patients receiving DOACs for NVAF had predominantly superior efficacy and safety. Patients who were treated with DOACs for acute VTE had non-inferior efficacy, but an overall superior saf...

What's the appropriate adjustment when an approved drug is in short supply?

May 26 2018

Author(s): Jerald Silverman

Source: Lab animal

No abstract

Common genitourinary catheters: a systematic approach for the radiologist

May 12 2018

Author(s): Helen Hr Kim,Sheryl Tulin-Silver,Richard N Yu,Jeanne S Chow

Source: Pediatric radiology

Catheters are commonly used to treat and diagnose urinary tract abnormalities in the pediatric population. This pictorial essay reviews commonly placed genitourinary catheters imaged by radiography, f...

Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models

May 07 2018

Author(s): Yeliz Yuva-Aydemir,Sandra Almeida,Fen-Biao Gao

Source: Trends in neurosciences

GGGGCC (G(4)C(2)) repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. An important issue is how repeat RNAs and their translation products, various dipeptide repeat (DPR) prot...

Impact of Intervention to Improve Nursing Home Resident-Staff Interactions and Engagement

May 03 2018

Author(s): Christine W Hartmann,Whitney L Mills,Camilla B Pimentel,Jennifer A Palmer,Rebecca S Allen,Shibei Zhao,Nancy J Wewiorski,Jennifer L Sullivan,Kristen Dillon,Valerie Clark,Dan R Berlowitz,Andrea Lynn Sno...

Source: The Gerontologist

BACKGROUND AND OBJECTIVES: For nursing home residents, positive interactions with staff and engagement in daily life contribute meaningfully to quality of life. We sought to improve these aspects of p...

Tibial tuberosity to trochlear groove distance and its association with patellofemoral osteoarthritis-related structural damage worsening: data from the osteoarthritis initiative

May 02 2018

Author(s): Arya Haj-Mirzaian,Ali Guermazi,Michael Hakky,Christopher Sereni,Bashir Zikria,Frank W Roemer,Miho J Tanaka,Andrew J Cosgarea,Shadpour Demehri

Source: European radiology

CONCLUSIONS: TT-TG distance was associated with simultaneous lateral patellofemoral OA-related structural damage and its worsening over 24 months. Abnormally lateralized tibial tuberosity may be consi...

Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging

Apr 29 2018

Author(s): Chuangqi Wang,Hee June Choi,Sung-Jin Kim,Aesha Desai,Namgyu Lee,Dohoon Kim,Yongho Bae,Kwonmoo Lee

Source: Nature communications

Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. He...

Bayesian nonparametric discovery of isoforms and individual specific quantification

Apr 29 2018

Author(s): Derek Aguiar,Li-Fang Cheng,Bianca Dumitrascu,Fantine Mordelet,Athma A Pai,Barbara E Engelhardt

Source: Nature communications

Most human protein-coding genes can be transcribed into multiple distinct mRNA isoforms. These alternative splicing patterns encourage molecular diversity, and dysregulation of isoform expression play...

Superolateral Hoffa's fat pad (SHFP) oedema and patellar cartilage volume loss: quantitative analysis using longitudinal data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium

Apr 14 2018

Author(s): Arya Haj-Mirzaian,Ali Guermazi,Nima Hafezi-Nejad,Christopher Sereni,Michael Hakky,David J Hunter,Bashir Zikria,Frank W Roemer,Shadpour Demehri

Source: European radiology

CONCLUSIONS: The presence of SHFP oedema could be considered as a predictor of future patellar cartilage loss and BML worsening, and an indicator of simultaneous cartilage, BML and osteophyte defects.

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

Apr 14 2018

Author(s): Melissa M Ledet,Robyn Anderson,Rebecca Harman,Aaron Muth,Paul R Thompson,Scott A Coonrod,Gerlinde R Van de Walle

Source: BMC cancer

CONCLUSION: We propose that our established mouse xenograft models will be useful for the study of mammary cancer in dogs and cats, and furthermore, that BB-CLA has potential as a novel therapeutic fo...

5'-Hydroxy-5'-homoaristeromycin: Synthesis and antiviral properties

Apr 10 2018

Author(s): Qi Chen,Chong Liu,Terry L Bowlin,Stewart W Schneller

Source: Bioorganic & medicinal chemistry letters

Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated...

Predator-secreted sulfolipids induce defensive responses in C. elegans

Mar 21 2018

Author(s): Zheng Liu,Maro J Kariya,Christopher D Chute,Amy K Pribadi,Sarah G Leinwand,Ada Tong,Kevin P Curran,Neelanjan Bose,Frank C Schroeder,Jagan Srinivasan,Sreekanth H Chalasani

Source: Nature communications

Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans a...

Phosphorylcholine surface modified flow diverter associated with reduced intimal hyperplasia

Mar 08 2018

Author(s): Jildaz Caroff,Takamitsu Tamura,Robert M King,Pedro N Lylyk,Erin T Langan,Olivia W Brooks,Frédéric Clarençon,John Michael Wainwright,Laurent Spelle,Miklos Marosfoi,Matthew J Gounis,Ajit S Puri

Source: Journal of neurointerventional surgery

CONCLUSION: OCT is a promising technique for immediate and long-term evaluation of flow diverter stent treatments. In an animal model, phosphorylcholine surface modified flow diverters induces less NI...

Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity

Feb 08 2018

Author(s): Mayuko Uehara,Zhabiz Solhjou,Naima Banouni,Vivek Kasinath,Ye Xiaqun,Li Dai,Osman Yilmam,Mine Yilmaz,Takaharu Ichimura,Paolo Fiorina,Paulo N Martins,Shunsuke Ohori,Indira Guleria,Omar H Maarouf,Stefan ...

Source: Scientific reports

Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI o...

Evaluation of a method to measure HHV-6B infection in vitro based on cell size

Jan 07 2018

Author(s): Aniuska Becerra-Artiles,Tessa Santoro,Lawrence J Stern

Source: Virology journal

CONCLUSIONS: The size-based method proved to be useful in monitoring HHV-6B infections for cultures where a substantial fraction of cells were infected and when monitored at longer times post-infectio...

Macrocognition in the Healthcare Built Environment (mHCBE): A Focused Ethnographic Study of "Neighborhoods" in a Pediatric Intensive Care Unit

Dec 16 2017

Author(s): Susan O'Hara,Robin Toft Klar,Emily S Patterson,Nancy S Morris,Judy Ascenzi,James C Fackler,Donna J Perry

Source: HERD

CONCLUSIONS: Results from this study support the intricate link between macrocognitive interactions and space syntax constructs within the HCBE. These findings help increase understanding of how use o...

Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

Dec 16 2017

Author(s): Jong Hun Kim,Eunjung Lee,Randall H Friedline,Sujin Suk,Dae Young Jung,Sezin Dagdeviren,Xiaodi Hu,Kunikazu Inashima,Hye Lim Noh,Jung Yeon Kwon,Aya Nambu,Jun R Huh,Myoung Sook Han,Roger J Davis,Amy S Le...

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Obesity-mediated inflammation is a major cause of insulin resistance, and macrophages play an important role in this process. The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticu...

Histopathology of periarticular non-hereditary heterotopic ossification

Dec 12 2017

Author(s): Kristin L Foley,Nader Hebela,Mary Ann Keenan,Robert J Pignolo

Source: Bone

In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the ...

IL-15 supports the generation of protective lung-resident memory CD4 T cells

Nov 30 2017

Author(s): T M Strutt,K Dhume,C M Finn,J H Hwang,C Castonguay,S L Swain,K K McKinstry

Source: Mucosal immunology

Tissue-resident memory T cells (T(RM)) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinc...

Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens

Nov 15 2017

Author(s): Anup Parchure,Neha Vyas,Satyajit Mayor

Source: Trends in cell biology

Morphogens are signaling molecules produced by a localized source, specifying cell fate in a graded manner. The source secretes morphogens into the extracellular milieu to activate various target gene...

Effects of a Self-Directed Nutrition Intervention Among Adults With Chronic Health Conditions

Jun 06 2017

Author(s): Meghan Baruth,Sara Wilcox,Danielle E Jake-Schoffman,Rebecca A Schlaff,Tatum M Goldufsky

Source: Health education & behavior : the official publication of the Society for Public Health Education

Chronic diseases are common among adults. A healthy diet may be beneficial for managing the consequences of such conditions. The purpose of this study was to evaluate the effects of a self-directed nu...

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