SMSF compound libraries
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| Unique small drug-like molecule libraries with diverse physiochemical profiles that occupy novel chemical space |
- 19F Fragment Library: 320 highly diverse fluorinated fragments (MW <350; ClopP <3.5; Fsp3 > 0.4)
- Fast fragment screening with 19F NMR spectroscopy
- Structures and formatting Information
- LOPAC (Library of Pharmacologically Active Compounds): 1280 compounds
- Impact most cellular processes and covers all major drug target classes
- Excellent starting point
- FDA Drug Libraries (US and International): 1280 compounds
- Approved drugs, including late stage clinical
- Move to clinic research quickly
- Diversity Set: 15,360 (5,000 + 10,000) compounds
- Broad chemical diversity with more than 1000 different scaffolds
- Central Nervous System targeted library: 5,000 compounds
- Compounds selected using CNS specific filters
- Epigenetics targeted library: 2,601 compounds
- Virtual docking and similarity search based
- Fragment-based library: 2,600 compounds
- Molecular weight less than 300
- cLogP less than 3
- ChemBridge (DIVERSet™): 30,000 compounds
- Cover the broad part of biological diversity space
- Recognized and proven for primary screening
- Covalent Fragment Library: 1300 compounds
- Epigenetics Compound Library: 181 compounds
- Tool for chemical genomics, epigenetic target identification in pharmacogenomics and other biological applications
- Structurally diverse, medicinally active, and cell permeable
- Kinase Inhibitor Library: 429 compounds
- Kinase inhibitors for high throughput and high content screening
- Bioactivity and safety confirmed by preclinical research and clinical trials
- Epigenetics Probe Collection: 37 Compounds
- Small drug-like molecules with in vitro IC50 or Kd <100nM
- >30-fold selectivity over proteins in the same family