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Total: displaying 10 out of 100 results
  • G12/13-mediated signaling stimulates hepatic glucose production and has a major impact on whole body glucose homeostasis

    lunes, noviembre 18, 2024
    Author(s): Srinivas Pittala,Dhanush Haspula,Yinghong Cui,Won-Mo Yang,Young-Bum Kim,Roger J Davis,Allison Wing,Yaron Rotman,Owen P McGuinness,Asuka Inoue,Jürgen Wess
    Source: Nature communications
  • Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance

    sábado, septiembre 28, 2024
    Author(s): Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Viruses
  • Commensal consortia decolonize Enterobacteriaceae via ecological control

    miércoles, septiembre 18, 2024
    Author(s): Munehiro Furuichi,Takaaki Kawaguchi,Marie-Madlen Pust,Keiko Yasuma-Mitobe,Damian R Plichta,Naomi Hasegawa,Takashi Ohya,Shakti K Bhattarai,Satoshi Sasajima,Yoshimasa Aoto,Timur Tuganbaev,Mizuki Yaginuma,Masahiro Ueda,Nobuyuki Okahashi,Kimiko Amafuji,Yuko Kiridoshi,Kayoko Sugita,Martin Stražar,Julian Avila-Pacheco,Kerry Pierce,Clary B Clish,Ashwin N Skelly,Masahira Hattori,Nobuhiro Nakamoto,Silvia Caballero,Jason M Norman,Bernat Olle,Takeshi Tanoue,Wataru Suda,Makoto Arita,Vanni Bucci,Koji Atarashi,Ramnik J Xavier,Kenya Honda
    Source: Nature
  • Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis

    viernes, abril 26, 2024
    Author(s): Esteban J Rozen,William Frantz,Kim Wigglesworth,Theadora Vessella,Hong S Zhou,Jason M Shohet
    Source: Molecular cancer therapeutics
  • FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

    domingo, marzo 24, 2024
    Author(s): Ke Cong,Nathan MacGilvary,Silviana Lee,Shannon G MacLeod,Jennifer Calvo,Min Peng,Arne Nedergaard Kousholt,Tovah A Day,Sharon B Cantor
    Source: Nature communications
  • Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics

    jueves, marzo 14, 2024
    Author(s): Mariana Noto Guillen,Carmen Li,Brittany Rosener,Amir Mitchell
    Source: Science (New York, N.Y.)
  • Contributions of Hyperactive Mutations in M(pro) from SARS-CoV-2 to Drug Resistance

    martes, marzo 12, 2024
    Author(s): Julia M Flynn,Sarah N Zvornicanin,Tenzin Tsepal,Ala M Shaqra,Nese Kurt Yilmaz,Weiping Jia,Stephanie Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
    Source: ACS infectious diseases
  • Functional Assay for Measuring Bacterial Degradation of Gemcitabine Chemotherapy

    lunes, septiembre 18, 2023
    Author(s): Serkan Sayin,Amir Mitchell
    Source: Bio-protocol
  • Development of ADS051, an oral, gut-restricted, small molecule neutrophil modulator for the treatment of neutrophil-mediated inflammatory diseases

    sábado, julio 01, 2023
    Author(s): Christopher K Murphy,Bharat Dixit,Frederick B Oleson,Roland E Dolle,Ronald Farquhar,Beth A McCormick
    Source: FEBS open bio
  • Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease

    viernes, junio 30, 2023
    Author(s): Julia M Flynn,Qiu Yu J Huang,Sarah N Zvornicanin,Gila Schneider-Nachum,Ala M Shaqra,Nese Kurt Yilmaz,Stephanie A Moquin,Dustin Dovala,Celia A Schiffer,Daniel N A Bolon
    Source: ACS infectious diseases
  • HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues

    sábado, mayo 27, 2023
    Author(s): Gordon J Lockbaum,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Desaboini Nageswara Rao,Ean Spielvogel,Sook-Kyung Lee,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: European journal of medicinal chemistry
  • Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

    miércoles, marzo 15, 2023
    Author(s): Ean Spielvogel,Sook-Kyung Lee,Shuntai Zhou,Gordon J Lockbaum,Mina Henes,Amy Sondgeroth,Klajdi Kosovrasti,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer,Ronald Swanstrom
    Source: eLife
  • Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

    viernes, febrero 03, 2023
    Author(s): Serkan Sayin,Brittany Rosener,Carmen G Li,Bao Ho,Olga Ponomarova,Doyle V Ward,Albertha J M Walhout,Amir Mitchell
    Source: eLife
  • Mutational fitness landscape and drug resistance

    lunes, enero 09, 2023
    Author(s): Julia Flynn,Neha Samant,Gily Schneider-Nachum,Tsepal Tenzin,Daniel N A Bolon
    Source: Current opinion in structural biology
  • Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes

    martes, noviembre 29, 2022
    Author(s): Scott M Leighow,Ben Landry,Michael J Lee,Shelly R Peyton,Justin R Pritchard
    Source: Cellular and molecular bioengineering
  • Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

    sábado, noviembre 19, 2022
    Author(s): Atanu Maiti,Adam K Hedger,Wazo Myint,Vanivilasini Balachandran,Jonathan K Watts,Celia A Schiffer,Hiroshi Matsuo
    Source: Nature communications
  • Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

    lunes, agosto 15, 2022
    Author(s): Sage E Foley,Michael J Dente,Xuqiu Lei,Benjamin F Sallis,Ethan B Loew,Mario Meza-Segura,Katherine A Fitzgerald,Beth A McCormick
    Source: mBio
  • Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

    martes, junio 21, 2022
    Author(s): Ala M Shaqra,Sarah N Zvornicanin,Qiu Yu J Huang,Gordon J Lockbaum,Mark Knapp,Laura Tandeske,David T Bakan,Julia Flynn,Daniel N A Bolon,Stephanie Moquin,Dustin Dovala,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Nature communications
  • Comprehensive fitness landscape of SARS-CoV-2 M(pro) reveals insights into viral resistance mechanisms

    lunes, junio 20, 2022
    Author(s): Julia M Flynn,Neha Samant,Gily Schneider-Nachum,David T Barkan,Nese Kurt Yilmaz,Celia A Schiffer,Stephanie A Moquin,Dustin Dovala,Daniel N A Bolon
    Source: eLife
  • Transfusing Convalescent Plasma as Post-Exposure Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Double-Blinded, Phase 2 Randomized, Controlled Trial

    martes, mayo 17, 2022
    Author(s): Shmuel Shoham,Evan M Bloch,Arturo Casadevall,Daniel Hanley,Bryan Lau,Kelly Gebo,Edward Cachay,Seble G Kassaye,James H Paxton,Jonathan Gerber,Adam C Levine,Arash Naeim,Judith Currier,Bela Patel,Elizabeth S Allen,Shweta Anjan,Lawrence Appel,Sheriza Baksh,Paul W Blair,Anthony Bowen,Patrick Broderick,Christopher A Caputo,Valerie Cluzet,Marie Elena Cordisco,Daniel Cruser,Stephan Ehrhardt,Donald Forthal,Yuriko Fukuta,Amy L Gawad,Thomas Gniadek,Jean Hammel,Moises A Huaman,Douglas A Jabs,Anne Jedlicka,Nicky Karlen,Sabra Klein,Oliver Laeyendecker,Karen Lane,Nichol McBee,Barry Meisenberg,Christian Merlo,Giselle Mosnaim,Han-Sol Park,Andrew Pekosz,Joann Petrini,William Rausch,David M Shade,Janna R Shapiro,J Robinson Singleton,Catherine Sutcliffe,David L Thomas,Anusha Yarava,Martin Zand,Jonathan M Zenilman,Aaron A R Tobian,David J Sullivan
    Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • Materials-driven approaches to understand extrinsic drug resistance in cancer

    jueves, abril 21, 2022
    Author(s): Justin R Pritchard,Michael J Lee,Shelly R Peyton
    Source: Soft matter
  • Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

    domingo, febrero 20, 2022
    Author(s): Jacqueto Zephyr,Desaboini Nageswara Rao,Sang V Vo,Mina Henes,Klajdi Kosovrasti,Ashley N Matthew,Adam K Hedger,Jennifer Timm,Elise T Chan,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of molecular biology
  • Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y

    miércoles, enero 19, 2022
    Author(s): Li Jiang,Neha Samant,Ping Liu,Mohan Somasundaran,Jeffrey D Jensen,Wayne A Marasco,Timothy F Kowalik,Celia A Schiffer,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
    Source: Journal of virology
  • Viral proteases: Structure, mechanism and inhibition

    sábado, diciembre 04, 2021
    Author(s): Jacqueto Zephyr,Nese Kurt Yilmaz,Celia A Schiffer
    Source: The Enzymes
  • Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

    jueves, septiembre 23, 2021
    Author(s): Mariana Paes Dias,Vivek Tripathi,Ingrid van der Heijden,Ke Cong,Eleni-Maria Manolika,Jinhyuk Bhin,Ewa Gogola,Panagiotis Galanos,Stefano Annunziato,Cor Lieftink,Miguel Andújar-Sánchez,Sanjiban Chakrabarty,Graeme C M Smith,Marieke van de Ven,Roderick L Beijersbergen,Jirina Bartkova,Sven Rottenberg,Sharon Cantor,Jiri Bartek,Arnab Ray Chaudhuri,Jos Jonkers
    Source: Molecular cell
  • Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis

    miércoles, septiembre 08, 2021
    Author(s): Sage E Foley,Christine Tuohy,Merran Dunford,Michael J Grey,Heidi De Luca,Caitlin Cawley,Rose L Szabady,Ana Maldonado-Contreras,Jean Marie Houghton,Doyle V Ward,Randall J Mrsny,Beth A McCormick
    Source: Microbiome
  • Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer"

    domingo, agosto 22, 2021
    Author(s): Sharon B Cantor
    Source: DNA repair
  • Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants

    miércoles, agosto 18, 2021
    Author(s): Desaboini Nageswara Rao,Jacqueto Zephyr,Mina Henes,Elise T Chan,Ashley N Matthew,Adam K Hedger,Hasahn L Conway,Mohsan Saeed,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Rapid signaling reactivation after targeted BRAF inhibition predicts the proliferation of individual melanoma cells from an isogenic population

    viernes, julio 30, 2021
    Author(s): Payam Khoshkenar,Emily Lowry,Amir Mitchell
    Source: Scientific reports
  • Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

    sábado, julio 03, 2021
    Author(s): Ke Cong,Min Peng,Arne Nedergaard Kousholt,Wei Ting C Lee,Silviana Lee,Sumeet Nayak,John Krais,Pamela S VanderVere-Carozza,Katherine S Pawelczak,Jennifer Calvo,Nicholas J Panzarino,John J Turchi,Neil Johnson,Jos Jonkers,Eli Rothenberg,Sharon B Cantor
    Source: Molecular cell
  • Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning

    jueves, junio 17, 2021
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of chemical information and modeling
  • Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning

    martes, marzo 30, 2021
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Introduction: Drug Resistance

    miércoles, marzo 24, 2021
    Author(s): Nese Kurt Yilmaz,Celia A Schiffer
    Source: Chemical reviews
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

    viernes, febrero 26, 2021
    Author(s): Daniel J Klionsky,Amal Kamal Abdel-Aziz,Sara Abdelfatah,Mahmoud Abdellatif,Asghar Abdoli,Steffen Abel,Hagai Abeliovich,Marie H Abildgaard,Yakubu Princely Abudu,Abraham Acevedo-Arozena,Iannis E Adamopoulos,Khosrow Adeli,Timon E Adolph,Annagrazia Adornetto,Elma Aflaki,Galila Agam,Anupam Agarwal,Bharat B Aggarwal,Maria Agnello,Patrizia Agostinis,Javed N Agrewala,Alexander Agrotis,Patricia V Aguilar,S Tariq Ahmad,Zubair M Ahmed,Ulises Ahumada-Castro,Sonja Aits,Shu Aizawa,Yunus Akkoc,Tonia Akoumianaki,Hafize Aysin Akpinar,Ahmed M Al-Abd,Lina Al-Akra,Abeer Al-Gharaibeh,Moulay A Alaoui-Jamali,Simon Alberti,Elísabet Alcocer-Gómez,Cristiano Alessandri,Muhammad Ali,M Abdul Alim Al-Bari,Saeb Aliwaini,Javad Alizadeh,Eugènia Almacellas,Alexandru Almasan,Alicia Alonso,Guillermo D Alonso,Nihal Altan-Bonnet,Dario C Altieri,Élida M C Álvarez,Sara Alves,Cristine Alves da Costa,Mazen M Alzaharna,Marialaura Amadio,Consuelo Amantini,Cristina Amaral,Susanna Ambrosio,Amal O Amer,Veena Ammanathan,Zhenyi An,Stig U Andersen,Shaida A Andrabi,Magaiver Andrade-Silva,Allen M Andres,Sabrina Angelini,David Ann,Uche C Anozie,Mohammad Y Ansari,Pedro Antas,Adam Antebi,Zuriñe Antón,Tahira Anwar,Lionel Apetoh,Nadezda Apostolova,Toshiyuki Araki,Yasuhiro Araki,Kohei Arasaki,Wagner L Araújo,Jun Araya,Catherine Arden,Maria-Angeles Arévalo,Sandro Arguelles,Esperanza Arias,Jyothi Arikkath,Hirokazu Arimoto,Aileen R Ariosa,Darius Armstrong-James,Laetitia Arnauné-Pelloquin,Angeles Aroca,Daniela S Arroyo,Ivica Arsov,Rubén Artero,Dalia Maria Lucia Asaro,Michael Aschner,Milad Ashrafizadeh,Osnat Ashur-Fabian,Atanas G Atanasov,Alicia K Au,Patrick Auberger,Holger W Auner,Laure Aurelian,Riccardo Autelli,Laura Avagliano,Yenniffer Ávalos,Sanja Aveic,Célia Alexandra Aveleira,Tamar Avin-Wittenberg,Yucel Aydin,Scott Ayton,Srinivas Ayyadevara,Maria Azzopardi,Misuzu Baba,Jonathan M Backer,Steven K Backues,Dong-Hun Bae,Ok-Nam Bae,Soo Han Bae,Eric H Baehrecke,Ahruem Baek,Seung-Hoon Baek,Sung Hee Baek,Giacinto Bagetta,Agnieszka Bagniewska-Zadworna,Hua Bai,Jie Bai,Xiyuan Bai,Yidong Bai,Nandadulal Bairagi,Shounak Baksi,Teresa Balbi,Cosima T Baldari,Walter Balduini,Andrea Ballabio,Maria Ballester,Salma Balazadeh,Rena Balzan,Rina Bandopadhyay,Sreeparna Banerjee,Sulagna Banerjee,Ágnes Bánréti,Yan Bao,Mauricio S Baptista,Alessandra Baracca,Cristiana Barbati,Ariadna Bargiela,Daniela Barilà,Peter G Barlow,Sami J Barmada,Esther Barreiro,George E Barreto,Jiri Bartek,Bonnie Bartel,Alberto Bartolome,Gaurav R Barve,Suresh H Basagoudanavar,Diane C Bassham,Robert C Bast,Alakananda Basu,Henri Batoko,Isabella Batten,Etienne E Baulieu,Bradley L Baumgarner,Jagadeesh Bayry,Rupert Beale,Isabelle Beau,Florian Beaumatin,Luiz R G Bechara,George R Beck,Michael F Beers,Jakob Begun,Christian Behrends,Georg M N Behrens,Roberto Bei,Eloy Bejarano,Shai Bel,Christian Behl,Amine Belaid,Naïma Belgareh-Touzé,Cristina Bellarosa,Francesca Belleudi,Melissa Belló Pérez,Raquel Bello-Morales,Jackeline Soares de Oliveira Beltran,Sebastián Beltran,Doris Mangiaracina Benbrook,Mykolas Bendorius,Bruno A Benitez,Irene Benito-Cuesta,Julien Bensalem,Martin W Berchtold,Sabina Berezowska,Daniele Bergamaschi,Matteo Bergami,Andreas Bergmann,Laura Berliocchi,Clarisse Berlioz-Torrent,Amélie Bernard,Lionel Berthoux,Cagri G Besirli,Sebastien Besteiro,Virginie M Betin,Rudi Beyaert,Jelena S Bezbradica,Kiran Bhaskar,Ingrid Bhatia-Kissova,Resham Bhattacharya,Sujoy Bhattacharya,Shalmoli Bhattacharyya,Md Shenuarin Bhuiyan,Sujit Kumar Bhutia,Lanrong Bi,Xiaolin Bi,Trevor J Biden,Krikor Bijian,Viktor A Billes,Nadine Binart,Claudia Bincoletto,Asa B Birgisdottir,Geir Bjorkoy,Gonzalo Blanco,Ana Blas-Garcia,Janusz Blasiak,Robert Blomgran,Klas Blomgren,Janice S Blum,Emilio Boada-Romero,Mirta Boban,Kathleen Boesze-Battaglia,Philippe Boeuf,Barry Boland,Pascale Bomont,Paolo Bonaldo,Srinivasa Reddy Bonam,Laura Bonfili,Juan S Bonifacino,Brian A Boone,Martin D Bootman,Matteo Bordi,Christoph Borner,Beat C Bornhauser,Gautam Borthakur,Jürgen Bosch,Santanu Bose,Luis M Botana,Juan Botas,Chantal M Boulanger,Michael E Boulton,Mathieu Bourdenx,Benjamin Bourgeois,Nollaig M Bourke,Guilhem Bousquet,Patricia Boya,Peter V Bozhkov,Luiz H M Bozi,Tolga O Bozkurt,Doug E Brackney,Christian H Brandts,Ralf J Braun,Gerhard H Braus,Roberto Bravo-Sagua,José M Bravo-San Pedro,Patrick Brest,Marie-Agnès Bringer,Alfredo Briones-Herrera,V Courtney Broaddus,Peter Brodersen,Jeffrey L Brodsky,Steven L Brody,Paola G Bronson,Jeff M Bronstein,Carolyn N Brown,Rhoderick E Brown,Patricia C Brum,John H Brumell,Nicola Brunetti-Pierri,Daniele Bruno,Robert J Bryson-Richardson,Cecilia Bucci,Carmen Buchrieser,Marta Bueno,Laura Elisa Buitrago-Molina,Simone Buraschi,Shilpa Buch,J Ross Buchan,Erin M Buckingham,Hikmet Budak,Mauricio Budini,Geert Bultynck,Florin Burada,Joseph R Burgoyne,M Isabel Burón,Victor Bustos,Sabrina Büttner,Elena Butturini,Aaron Byrd,Isabel Cabas,Sandra Cabrera-Benitez,Ken Cadwell,Jingjing Cai,Lu Cai,Qian Cai,Montserrat Cairó,Jose A Calbet,Guy A Caldwell,Kim A Caldwell,Jarrod A Call,Riccardo Calvani,Ana C Calvo,Miguel Calvo-Rubio Barrera,Niels Os Camara,Jacques H Camonis,Nadine Camougrand,Michelangelo Campanella,Edward M Campbell,François-Xavier Campbell-Valois,Silvia Campello,Ilaria Campesi,Juliane C Campos,Olivier Camuzard,Jorge Cancino,Danilo Candido de Almeida,Laura Canesi,Isabella Caniggia,Barbara Canonico,Carles Cantí,Bin Cao,Michele Caraglia,Beatriz Caramés,Evie H Carchman,Elena Cardenal-Muñoz,Cesar Cardenas,Luis Cardenas,Sandra M Cardoso,Jennifer S Carew,Georges F Carle,Gillian Carleton,Silvia Carloni,Didac Carmona-Gutierrez,Leticia A Carneiro,Oliana Carnevali,Julian M Carosi,Serena Carra,Alice Carrier,Lucie Carrier,Bernadette Carroll,A Brent Carter,Andreia Neves Carvalho,Magali Casanova,Caty Casas,Josefina Casas,Chiara Cassioli,Eliseo F Castillo,Karen Castillo,Sonia Castillo-Lluva,Francesca Castoldi,Marco Castori,Ariel F Castro,Margarida Castro-Caldas,Javier Castro-Hernandez,Susana Castro-Obregon,Sergio D Catz,Claudia Cavadas,Federica Cavaliere,Gabriella Cavallini,Maria Cavinato,Maria L Cayuela,Paula Cebollada Rica,Valentina Cecarini,Francesco Cecconi,Marzanna Cechowska-Pasko,Simone Cenci,Victòria Ceperuelo-Mallafré,João J Cerqueira,Janete M Cerutti,Davide Cervia,Vildan Bozok Cetintas,Silvia Cetrullo,Han-Jung Chae,Andrei S Chagin,Chee-Yin Chai,Gopal Chakrabarti,Oishee Chakrabarti,Tapas Chakraborty,Trinad Chakraborty,Mounia Chami,Georgios Chamilos,David W Chan,Edmond Y W Chan,Edward D Chan,H Y Edwin Chan,Helen H Chan,Hung Chan,Matthew T V Chan,Yau Sang Chan,Partha K Chandra,Chih-Peng Chang,Chunmei Chang,Hao-Chun Chang,Kai Chang,Jie Chao,Tracey Chapman,Nicolas Charlet-Berguerand,Samrat Chatterjee,Shail K Chaube,Anu Chaudhary,Santosh Chauhan,Edward Chaum,Frédéric Checler,Michael E Cheetham,Chang-Shi Chen,Guang-Chao Chen,Jian-Fu Chen,Liam L Chen,Leilei Chen,Lin Chen,Mingliang Chen,Mu-Kuan Chen,Ning Chen,Quan Chen,Ruey-Hwa Chen,Shi Chen,Wei Chen,Weiqiang Chen,Xin-Ming Chen,Xiong-Wen Chen,Xu Chen,Yan Chen,Ye-Guang Chen,Yingyu Chen,Yongqiang Chen,Yu-Jen Chen,Yue-Qin Chen,Zhefan Stephen Chen,Zhi Chen,Zhi-Hua Chen,Zhijian J Chen,Zhixiang Chen,Hanhua Cheng,Jun Cheng,Shi-Yuan Cheng,Wei Cheng,Xiaodong Cheng,Xiu-Tang Cheng,Yiyun Cheng,Zhiyong Cheng,Zhong Chen,Heesun Cheong,Jit Kong Cheong,Boris V Chernyak,Sara Cherry,Chi Fai Randy Cheung,Chun Hei Antonio Cheung,King-Ho Cheung,Eric Chevet,Richard J Chi,Alan Kwok Shing Chiang,Ferdinando Chiaradonna,Roberto Chiarelli,Mario Chiariello,Nathalia Chica,Susanna Chiocca,Mario Chiong,Shih-Hwa Chiou,Abhilash I Chiramel,Valerio Chiurchiù,Dong-Hyung Cho,Seong-Kyu Choe,Augustine M K Choi,Mary E Choi,Kamalika Roy Choudhury,Norman S Chow,Charleen T Chu,Jason P Chua,John Jia En Chua,Hyewon Chung,Kin Pan Chung,Seockhoon Chung,So-Hyang Chung,Yuen-Li Chung,Valentina Cianfanelli,Iwona A Ciechomska,Mariana Cifuentes,Laura Cinque,Sebahattin Cirak,Mara Cirone,Michael J Clague,Robert Clarke,Emilio Clementi,Eliana M Coccia,Patrice Codogno,Ehud Cohen,Mickael M Cohen,Tania Colasanti,Fiorella Colasuonno,Robert A Colbert,Anna Colell,Miodrag Čolić,Nuria S Coll,Mark O Collins,María I Colombo,Daniel A Colón-Ramos,Lydie Combaret,Sergio Comincini,Márcia R Cominetti,Antonella Consiglio,Andrea Conte,Fabrizio Conti,Viorica Raluca Contu,Mark R Cookson,Kevin M Coombs,Isabelle Coppens,Maria Tiziana Corasaniti,Dale P Corkery,Nils Cordes,Katia Cortese,Maria do Carmo Costa,Sarah Costantino,Paola Costelli,Ana Coto-Montes,Peter J Crack,Jose L Crespo,Alfredo Criollo,Valeria Crippa,Riccardo Cristofani,Tamas Csizmadia,Antonio Cuadrado,Bing Cui,Jun Cui,Yixian Cui,Yong Cui,Emmanuel Culetto,Andrea C Cumino,Andrey V Cybulsky,Mark J Czaja,Stanislaw J Czuczwar,Stefania D'Adamo,Marcello D'Amelio,Daniela D'Arcangelo,Andrew C D'Lugos,Gabriella D'Orazi,James A da Silva,Hormos Salimi Dafsari,Ruben K Dagda,Yasin Dagdas,Maria Daglia,Xiaoxia Dai,Yun Dai,Yuyuan Dai,Jessica Dal Col,Paul Dalhaimer,Luisa Dalla Valle,Tobias Dallenga,Guillaume Dalmasso,Markus Damme,Ilaria Dando,Nico P Dantuma,April L Darling,Hiranmoy Das,Srinivasan Dasarathy,Santosh K Dasari,Srikanta Dash,Oliver Daumke,Adrian N Dauphinee,Jeffrey S Davies,Valeria A Dávila,Roger J Davis,Tanja Davis,Sharadha Dayalan Naidu,Francesca De Amicis,Karolien De Bosscher,Francesca De Felice,Lucia De Franceschi,Chiara De Leonibus,Mayara G de Mattos Barbosa,Guido R Y De Meyer,Angelo De Milito,Cosimo De Nunzio,Clara De Palma,Mauro De Santi,Claudio De Virgilio,Daniela De Zio,Jayanta Debnath,Brian J DeBosch,Jean-Paul Decuypere,Mark A Deehan,Gianluca Deflorian,James DeGregori,Benjamin Dehay,Gabriel Del Rio,Joe R Delaney,Lea M D Delbridge,Elizabeth Delorme-Axford,M Victoria Delpino,Francesca Demarchi,Vilma Dembitz,Nicholas D Demers,Hongbin Deng,Zhiqiang Deng,Joern Dengjel,Paul Dent,Donna Denton,Melvin L DePamphilis,Channing J Der,Vojo Deretic,Albert Descoteaux,Laura Devis,Sushil Devkota,Olivier Devuyst,Grant Dewson,Mahendiran Dharmasivam,Rohan Dhiman,Diego di Bernardo,Manlio Di Cristina,Fabio Di Domenico,Pietro Di Fazio,Alessio Di Fonzo,Giovanni Di Guardo,Gianni M Di Guglielmo,Luca Di Leo,Chiara Di Malta,Alessia Di Nardo,Martina Di Rienzo,Federica Di Sano,George Diallinas,Jiajie Diao,Guillermo Diaz-Araya,Inés Díaz-Laviada,Jared M Dickinson,Marc Diederich,Mélanie Dieudé,Ivan Dikic,Shiping Ding,Wen-Xing Ding,Luciana Dini,Jelena Dinić,Miroslav Dinic,Albena T Dinkova-Kostova,Marc S Dionne,Jörg H W Distler,Abhinav Diwan,Ian M C Dixon,Mojgan Djavaheri-Mergny,Ina Dobrinski,Oxana Dobrovinskaya,Radek Dobrowolski,Renwick C J Dobson,Jelena Đokić,Serap Dokmeci Emre,Massimo Donadelli,Bo Dong,Xiaonan Dong,Zhiwu Dong,Gerald W Dorn Ii,Volker Dotsch,Huan Dou,Juan Dou,Moataz Dowaidar,Sami Dridi,Liat Drucker,Ailian Du,Caigan Du,Guangwei Du,Hai-Ning Du,Li-Lin Du,André du Toit,Shao-Bin Duan,Xiaoqiong Duan,Sónia P Duarte,Anna Dubrovska,Elaine A Dunlop,Nicolas Dupont,Raúl V Durán,Bilikere S Dwarakanath,Sergey A Dyshlovoy,Darius Ebrahimi-Fakhari,Leopold Eckhart,Charles L Edelstein,Thomas Efferth,Eftekhar Eftekharpour,Ludwig Eichinger,Nabil Eid,Tobias Eisenberg,N Tony Eissa,Sanaa Eissa,Miriam Ejarque,Abdeljabar El Andaloussi,Nazira El-Hage,Shahenda El-Naggar,Anna Maria Eleuteri,Eman S El-Shafey,Mohamed Elgendy,Aristides G Eliopoulos,María M Elizalde,Philip M Elks,Hans-Peter Elsasser,Eslam S Elsherbiny,Brooke M Emerling,N C Tolga Emre,Christina H Eng,Nikolai Engedal,Anna-Mart Engelbrecht,Agnete S T Engelsen,Jorrit M Enserink,Ricardo Escalante,Audrey Esclatine,Mafalda Escobar-Henriques,Eeva-Liisa Eskelinen,Lucile Espert,Makandjou-Ola Eusebio,Gemma Fabrias,Cinzia Fabrizi,Antonio Facchiano,Francesco Facchiano,Bengt Fadeel,Claudio Fader,Alex C Faesen,W Douglas Fairlie,Alberto Falcó,Bjorn H Falkenburger,Daping Fan,Jie Fan,Yanbo Fan,Evandro F Fang,Yanshan Fang,Yognqi Fang,Manolis Fanto,Tamar Farfel-Becker,Mathias Faure,Gholamreza Fazeli,Anthony O Fedele,Arthur M Feldman,Du Feng,Jiachun Feng,Lifeng Feng,Yibin Feng,Yuchen Feng,Wei Feng,Thais Fenz Araujo,Thomas A Ferguson,Álvaro F Fernández,Jose C Fernandez-Checa,Sonia Fernández-Veledo,Alisdair R Fernie,Anthony W Ferrante,Alessandra Ferraresi,Merari F Ferrari,Julio C B Ferreira,Susan Ferro-Novick,Antonio Figueras,Riccardo Filadi,Nicoletta Filigheddu,Eduardo Filippi-Chiela,Giuseppe Filomeni,Gian Maria Fimia,Vittorio Fineschi,Francesca Finetti,Steven Finkbeiner,Edward A Fisher,Paul B Fisher,Flavio Flamigni,Steven J Fliesler,Trude H Flo,Ida Florance,Oliver Florey,Tullio Florio,Erika Fodor,Carlo Follo,Edward A Fon,Antonella Forlino,Francesco Fornai,Paola Fortini,Anna Fracassi,Alessandro Fraldi,Brunella Franco,Rodrigo Franco,Flavia Franconi,Lisa B Frankel,Scott L Friedman,Leopold F Fröhlich,Gema Frühbeck,Jose M Fuentes,Yukio Fujiki,Naonobu Fujita,Yuuki Fujiwara,Mitsunori Fukuda,Simone Fulda,Luc Furic,Norihiko Furuya,Carmela Fusco,Michaela U Gack,Lidia Gaffke,Sehamuddin Galadari,Alessia Galasso,Maria F Galindo,Sachith Gallolu Kankanamalage,Lorenzo Galluzzi,Vincent Galy,Noor Gammoh,Boyi Gan,Ian G Ganley,Feng Gao,Hui Gao,Minghui Gao,Ping Gao,Shou-Jiang Gao,Wentao Gao,Xiaobo Gao,Ana Garcera,Maria Noé Garcia,Verónica E Garcia,Francisco García-Del Portillo,Vega Garcia-Escudero,Aracely Garcia-Garcia,Marina Garcia-Macia,Diana García-Moreno,Carmen Garcia-Ruiz,Patricia García-Sanz,Abhishek D Garg,Ricardo Gargini,Tina Garofalo,Robert F Garry,Nils C Gassen,Damian Gatica,Liang Ge,Wanzhong Ge,Ruth Geiss-Friedlander,Cecilia Gelfi,Pascal Genschik,Ian E Gentle,Valeria Gerbino,Christoph Gerhardt,Kyla Germain,Marc Germain,David A Gewirtz,Elham Ghasemipour Afshar,Saeid Ghavami,Alessandra Ghigo,Manosij Ghosh,Georgios Giamas,Claudia Giampietri,Alexandra Giatromanolaki,Gary E Gibson,Spencer B Gibson,Vanessa Ginet,Edward Giniger,Carlotta Giorgi,Henrique Girao,Stephen E Girardin,Mridhula Giridharan,Sandy Giuliano,Cecilia Giulivi,Sylvie Giuriato,Julien Giustiniani,Alexander Gluschko,Veit Goder,Alexander Goginashvili,Jakub Golab,David C Goldstone,Anna Golebiewska,Luciana R Gomes,Rodrigo Gomez,Rubén Gómez-Sánchez,Maria Catalina Gomez-Puerto,Raquel Gomez-Sintes,Qingqiu Gong,Felix M Goni,Javier González-Gallego,Tomas Gonzalez-Hernandez,Rosa A Gonzalez-Polo,Jose A Gonzalez-Reyes,Patricia González-Rodríguez,Ing Swie Goping,Marina S Gorbatyuk,Nikolai V Gorbunov,Kıvanç Görgülü,Roxana M Gorojod,Sharon M Gorski,Sandro Goruppi,Cecilia Gotor,Roberta A Gottlieb,Illana Gozes,Devrim Gozuacik,Martin Graef,Markus H Gräler,Veronica Granatiero,Daniel Grasso,Joshua P Gray,Douglas R Green,Alexander Greenhough,Stephen L Gregory,Edward F Griffin,Mark W Grinstaff,Frederic Gros,Charles Grose,Angelina S Gross,Florian Gruber,Paolo Grumati,Tilman Grune,Xueyan Gu,Jun-Lin Guan,Carlos M Guardia,Kishore Guda,Flora Guerra,Consuelo Guerri,Prasun Guha,Carlos Guillén,Shashi Gujar,Anna Gukovskaya,Ilya Gukovsky,Jan Gunst,Andreas Günther,Anyonya R Guntur,Chuanyong Guo,Chun Guo,Hongqing Guo,Lian-Wang Guo,Ming Guo,Pawan Gupta,Shashi Kumar Gupta,Swapnil Gupta,Veer Bala Gupta,Vivek Gupta,Asa B Gustafsson,David D Gutterman,Ranjitha H B,Annakaisa Haapasalo,James E Haber,Aleksandra Hać,Shinji Hadano,Anders J Hafrén,Mansour Haidar,Belinda S Hall,Gunnel Halldén,Anne Hamacher-Brady,Andrea Hamann,Maho Hamasaki,Weidong Han,Malene Hansen,Phyllis I Hanson,Zijian Hao,Masaru Harada,Ljubica Harhaji-Trajkovic,Nirmala Hariharan,Nigil Haroon,James Harris,Takafumi Hasegawa,Noor Hasima Nagoor,Jeffrey A Haspel,Volker Haucke,Wayne D Hawkins,Bruce A Hay,Cole M Haynes,Soren B Hayrabedyan,Thomas S Hays,Congcong He,Qin He,Rong-Rong He,You-Wen He,Yu-Ying He,Yasser Heakal,Alexander M Heberle,J Fielding Hejtmancik,Gudmundur Vignir Helgason,Vanessa Henkel,Marc Herb,Alexander Hergovich,Anna Herman-Antosiewicz,Agustín Hernández,Carlos Hernandez,Sergio Hernandez-Diaz,Virginia Hernandez-Gea,Amaury Herpin,Judit Herreros,Javier H Hervás,Daniel Hesselson,Claudio Hetz,Volker T Heussler,Yujiro Higuchi,Sabine Hilfiker,Joseph A Hill,William S Hlavacek,Emmanuel A Ho,Idy H T Ho,Philip Wing-Lok Ho,Shu-Leong Ho,Wan Yun Ho,G Aaron Hobbs,Mark Hochstrasser,Peter H M Hoet,Daniel Hofius,Paul Hofman,Annika Höhn,Carina I Holmberg,Jose R Hombrebueno,Chang-Won Hong Yi-Ren Hong,Lora V Hooper,Thorsten Hoppe,Rastislav Horos,Yujin Hoshida,I-Lun Hsin,Hsin-Yun Hsu,Bing Hu,Dong Hu,Li-Fang Hu,Ming Chang Hu,Ronggui Hu,Wei Hu,Yu-Chen Hu,Zhuo-Wei Hu,Fang Hua,Jinlian Hua,Yingqi Hua,Chongmin Huan,Canhua Huang,Chuanshu Huang,Chuanxin Huang,Chunling Huang,Haishan Huang,Kun Huang,Michael L H Huang,Rui Huang,Shan Huang,Tianzhi Huang,Xing Huang,Yuxiang Jack Huang,Tobias B Huber,Virginie Hubert,Christian A Hubner,Stephanie M Hughes,William E Hughes,Magali Humbert,Gerhard Hummer,James H Hurley,Sabah Hussain,Salik Hussain,Patrick J Hussey,Martina Hutabarat,Hui-Yun Hwang,Seungmin Hwang,Antonio Ieni,Fumiyo Ikeda,Yusuke Imagawa,Yuzuru Imai,Carol Imbriano,Masaya Imoto,Denise M Inman,Ken Inoki,Juan Iovanna,Renato V Iozzo,Giuseppe Ippolito,Javier E Irazoqui,Pablo Iribarren,Mohd Ishaq,Makoto Ishikawa,Nestor Ishimwe,Ciro Isidoro,Nahed 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Jung,Sung-Chul Jung,Yong Keun Jung,Heinz Jungbluth,Johannes Jungverdorben,Steffen Just,Kai Kaarniranta,Allen Kaasik,Tomohiro Kabuta,Daniel Kaganovich,Alon Kahana,Renate Kain,Shinjo Kajimura,Maria Kalamvoki,Manjula Kalia,Danuta S Kalinowski,Nina Kaludercic,Ioanna Kalvari,Joanna Kaminska,Vitaliy O Kaminskyy,Hiromitsu Kanamori,Keizo Kanasaki,Chanhee Kang,Rui Kang,Sang Sun Kang,Senthilvelrajan Kaniyappan,Tomotake Kanki,Thirumala-Devi Kanneganti,Anumantha G Kanthasamy,Arthi Kanthasamy,Marc Kantorow,Orsolya Kapuy,Michalis V Karamouzis,Md Razaul Karim,Parimal Karmakar,Rajesh G Katare,Masaru Kato,Stefan H E Kaufmann,Anu Kauppinen,Gur P Kaushal,Susmita Kaushik,Kiyoshi Kawasaki,Kemal Kazan,Po-Yuan Ke,Damien J Keating,Ursula Keber,John H Kehrl,Kate E Keller,Christian W Keller,Jongsook Kim Kemper,Candia M Kenific,Oliver Kepp,Stephanie Kermorgant,Andreas Kern,Robin Ketteler,Tom G Keulers,Boris Khalfin,Hany Khalil,Bilon Khambu,Shahid Y Khan,Vinoth Kumar Megraj Khandelwal,Rekha Khandia,Widuri Kho,Noopur V Khobrekar,Sataree Khuansuwan,Mukhran Khundadze,Samuel A Killackey,Dasol Kim,Deok Ryong Kim,Do-Hyung Kim,Dong-Eun Kim,Eun Young Kim,Eun-Kyoung Kim,Hak-Rim Kim,Hee-Sik Kim,None Hyung-Ryong Kim,Jeong Hun Kim,Jin Kyung Kim,Jin-Hoi Kim,Joungmok Kim,Ju Hwan Kim,Keun Il Kim,Peter K Kim,Seong-Jun Kim,Scot R Kimball,Adi Kimchi,Alec C Kimmelman,Tomonori Kimura,Matthew A King,Kerri J Kinghorn,Conan G Kinsey,Vladimir Kirkin,Lorrie A Kirshenbaum,Sergey L Kiselev,Shuji Kishi,Katsuhiko Kitamoto,Yasushi Kitaoka,Kaio Kitazato,Richard N Kitsis,Josef T Kittler,Ole Kjaerulff,Peter S Klein,Thomas Klopstock,Jochen Klucken,Helene Knævelsrud,Roland L Knorr,Ben C B Ko,Fred Ko,Jiunn-Liang Ko,Hotaka Kobayashi,Satoru Kobayashi,Ina Koch,Jan C Koch,Ulrich Koenig,Donat Kögel,Young Ho Koh,Masato Koike,Sepp D Kohlwein,Nur M Kocaturk,Masaaki Komatsu,Jeannette König,Toru Kono,Benjamin T Kopp,Tamas Korcsmaros,Gözde Korkmaz,Viktor I Korolchuk,Mónica Suárez Korsnes,Ali Koskela,Janaiah Kota,Yaichiro Kotake,Monica L Kotler,Yanjun Kou,Michael I Koukourakis,Evangelos Koustas,Attila L Kovacs,Tibor Kovács,Daisuke Koya,Tomohiro Kozako,Claudine Kraft,Dimitri Krainc,Helmut Krämer,Anna D Krasnodembskaya,Carole Kretz-Remy,Guido Kroemer,Nicholas T Ktistakis,Kazuyuki Kuchitsu,Sabine Kuenen,Lars Kuerschner,Thomas Kukar,Ajay Kumar,Ashok Kumar,Deepak Kumar,Dhiraj Kumar,Sharad Kumar,Shinji Kume,Caroline Kumsta,Chanakya N Kundu,Mondira Kundu,Ajaikumar B Kunnumakkara,Lukasz Kurgan,Tatiana G Kutateladze,Ozlem Kutlu,SeongAe Kwak,Ho Jeong Kwon,Taeg Kyu Kwon,Yong Tae Kwon,Irene Kyrmizi,Albert La Spada,Patrick Labonté,Sylvain Ladoire,Ilaria Laface,Frank Lafont,Diane C Lagace,Vikramjit Lahiri,Zhibing Lai,Angela S Laird,Aparna Lakkaraju,Trond Lamark,Sheng-Hui Lan,Ane Landajuela,Darius J R Lane,Jon D Lane,Charles H Lang,Carsten Lange,Ülo Langel,Rupert Langer,Pierre Lapaquette,Jocelyn Laporte,Nicholas F LaRusso,Isabel Lastres-Becker,Wilson Chun Yu Lau,Gordon W Laurie,Sergio Lavandero,Betty Yuen Kwan Law,Helen Ka-Wai Law,Rob Layfield,Weidong Le,Herve Le Stunff,Alexandre Y Leary,Jean-Jacques Lebrun,Lionel Y W Leck,Jean-Philippe Leduc-Gaudet,Changwook Lee,Chung-Pei Lee,Da-Hye Lee,Edward B Lee,Erinna F Lee,Gyun Min Lee,He-Jin Lee,Heung Kyu Lee,Jae Man Lee,Jason S Lee,Jin-A Lee,Joo-Yong Lee,Jun Hee Lee,Michael Lee,Min Goo Lee,Min Jae Lee,Myung-Shik Lee,Sang Yoon Lee,Seung-Jae Lee,Stella Y Lee,Sung Bae Lee,Won Hee Lee,Ying-Ray Lee,Yong-Ho Lee,Youngil Lee,Christophe Lefebvre,Renaud Legouis,Yu L Lei,Yuchen Lei,Sergey Leikin,Gerd Leitinger,Leticia Lemus,Shuilong Leng,Olivia Lenoir,Guido Lenz,Heinz Josef Lenz,Paola Lenzi,Yolanda León,Andréia M Leopoldino,Christoph Leschczyk,Stina Leskelä,Elisabeth Letellier,Chi-Ting Leung,Po Sing Leung,Jeremy S Leventhal,Beth Levine,Patrick A Lewis,Klaus Ley,Bin Li,Da-Qiang Li,Jianming Li,Jing Li,Jiong Li,Ke Li,Liwu Li,Mei Li,Min Li,Min Li,Ming Li,Mingchuan Li,Pin-Lan Li,Ming-Qing Li,Qing Li,Sheng Li,Tiangang Li,Wei Li,Wenming Li,Xue Li,Yi-Ping Li,Yuan Li,Zhiqiang Li,Zhiyong Li,Zhiyuan Li,Jiqin Lian,Chengyu Liang,Qiangrong Liang,Weicheng Liang,Yongheng Liang,YongTian Liang,Guanghong Liao,Lujian Liao,Mingzhi Liao,Yung-Feng Liao,Mariangela Librizzi,Pearl P Y Lie,Mary A Lilly,Hyunjung J Lim,Thania R R Lima,Federica Limana,Chao Lin,Chih-Wen Lin,Dar-Shong Lin,Fu-Cheng Lin,Jiandie D Lin,Kurt M Lin,Kwang-Huei Lin,Liang-Tzung Lin,Pei-Hui Lin,Qiong Lin,Shaofeng Lin,Su-Ju Lin,Wenyu Lin,Xueying Lin,Yao-Xin Lin,Yee-Shin Lin,Rafael Linden,Paula Lindner,Shuo-Chien Ling,Paul Lingor,Amelia K Linnemann,Yih-Cherng Liou,Marta M Lipinski,Saška Lipovšek,Vitor A Lira,Natalia Lisiak,Paloma B Liton,Chao Liu,Ching-Hsuan Liu,Chun-Feng Liu,Cui Hua Liu,Fang Liu,Hao Liu,Hsiao-Sheng Liu,Hua-Feng Liu,Huifang Liu,Jia Liu,Jing Liu,Julia Liu,Leyuan Liu,Longhua Liu,Meilian Liu,Qin Liu,Wei Liu,Wende Liu,Xiao-Hong Liu,Xiaodong Liu,Xingguo Liu,Xu Liu,Xuedong Liu,Yanfen Liu,Yang Liu,Yang Liu,Yueyang Liu,Yule Liu,J Andrew Livingston,Gerard Lizard,Jose M Lizcano,Senka 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F Macleod,Sandra Maday,Frank Madeo,Muniswamy Madesh,Tobias Madl,Julio Madrigal-Matute,Akiko Maeda,Yasuhiro Maejima,Marta Magarinos,Poornima Mahavadi,Emiliano Maiani,Kenneth Maiese,Panchanan Maiti,Maria Chiara Maiuri,Barbara Majello,Michael B Major,Elena Makareeva,Fayaz Malik,Karthik Mallilankaraman,Walter Malorni,Alina Maloyan,Najiba Mammadova,Gene Chi Wai Man,Federico Manai,Joseph D Mancias,Eva-Maria Mandelkow,Michael A Mandell,Angelo A Manfredi,Masoud H Manjili,Ravi Manjithaya,Patricio Manque,Bella B Manshian,Raquel Manzano,Claudia Manzoni,Kai Mao,Cinzia Marchese,Sandrine Marchetti,Anna Maria Marconi,Fabrizio Marcucci,Stefania Mardente,Olga A Mareninova,Marta Margeta,Muriel Mari,Sara Marinelli,Oliviero Marinelli,Guillermo Mariño,Sofia Mariotto,Richard S Marshall,Mark R Marten,Sascha Martens,Alexandre P J Martin,Katie R Martin,Sara Martin,Shaun Martin,Adrián Martín-Segura,Miguel A Martín-Acebes,Inmaculada Martin-Burriel,Marcos Martin-Rincon,Paloma Martin-Sanz,José A Martina,Wim Martinet,Aitor Martinez,Ana Martinez,Jennifer Martinez,Moises Martinez Velazquez,Nuria Martinez-Lopez,Marta Martinez-Vicente,Daniel O Martins,Joilson O Martins,Waleska K Martins,Tania Martins-Marques,Emanuele Marzetti,Shashank Masaldan,Celine Masclaux-Daubresse,Douglas G Mashek,Valentina Massa,Lourdes Massieu,Glenn R Masson,Laura Masuelli,Anatoliy I Masyuk,Tetyana V Masyuk,Paola Matarrese,Ander Matheu,Satoaki Matoba,Sachiko Matsuzaki,Pamela Mattar,Alessandro Matte,Domenico Mattoscio,José L Mauriz,Mario Mauthe,Caroline Mauvezin,Emanual Maverakis,Paola Maycotte,Johanna Mayer,Gianluigi Mazzoccoli,Cristina Mazzoni,Joseph R Mazzulli,Nami McCarty,Christine McDonald,Mitchell R McGill,Sharon L McKenna,BethAnn McLaughlin,Fionn McLoughlin,Mark A McNiven,Thomas G McWilliams,Fatima Mechta-Grigoriou,Tania Catarina Medeiros,Diego L Medina,Lynn A Megeney,Klara Megyeri,Maryam Mehrpour,Jawahar L Mehta,Alfred J Meijer,Annemarie H Meijer,Jakob Mejlvang,Alicia Meléndez,Annette Melk,Gonen 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    Source: Autophagy
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    Author(s): Jennifer A Calvo,Briana Fritchman,Desiree Hernandez,Nicole S Persky,Cory M Johannessen,Federica Piccioni,Brian A Kelch,Sharon B Cantor
    Source: Molecular cancer research : MCR
  • Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

    jueves, enero 07, 2021
    Author(s): Ashley N Matthew,Florian Leidner,Gordon J Lockbaum,Mina Henes,Jacqueto Zephyr,Shurong Hou,Desaboini Nageswara Rao,Jennifer Timm,Linah N Rusere,Debra A Ragland,Janet L Paulsen,Kristina Prachanronarong,Djade I Soumana,Ellen A Nalivaika,Nese Kurt Yilmaz,Akbar Ali,Celia A Schiffer
    Source: Chemical reviews
  • A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

    viernes, diciembre 18, 2020
    Author(s): Myoung Sook Han,Rachel J Perry,João-Paulo Camporez,Philipp E Scherer,Gerald I Shulman,Guangping Gao,Roger J Davis
    Source: Genes & development
  • Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

    lunes, noviembre 30, 2020
    Author(s): Brittany Rosener,Serkan Sayin,Peter O Oluoch,Aurian P García González,Hirotada Mori,Albertha Jm Walhout,Amir Mitchell
    Source: eLife
  • FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

    domingo, agosto 16, 2020
    Author(s): Sanket Awate,Joshua A Sommers,Arindam Datta,Sumeet Nayak,Marina A Bellani,Olivia Yang,Christopher A Dunn,Claudia M Nicolae,George-Lucian Moldovan,Michael M Seidman,Sharon B Cantor,Robert M Brosh
    Source: Nucleic acids research
  • JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

    miércoles, julio 01, 2020
    Author(s): Elisa Manieri,Cintia Folgueira,María Elena Rodríguez,Luis Leiva-Vega,Laura Esteban-Lafuente,Chaobo Chen,Francisco Javier Cubero,Tamera Barrett,Julie Cavanagh-Kyros,Davide Seruggia,Alejandro Rosell,Fátima Sanchez-Cabo,Manuel Jose Gómez,Maria J Monte,Jose J G Marin,Roger J Davis,Alfonso Mora,Guadalupe Sabio
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

    viernes, abril 03, 2020
    Author(s): Ashley N Matthew,Jacqueto Zephyr,Desaboini Nageswara Rao,Mina Henes,Wasih Kamran,Klajdi Kosovrasti,Adam K Hedger,Gordon J Lockbaum,Jennifer Timm,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: mBio
  • Microcin H47: A Class IIb Microcin with Potent Activity Against Multidrug Resistant Enterobacteriaceae

    miércoles, febrero 26, 2020
    Author(s): Jacob D Palmer,Benedikt M Mortzfeld,Emma Piattelli,Mark W Silby,Beth A McCormick,Vanni Bucci
    Source: ACS infectious diseases
  • Reduction of Inappropriate Antibiotic Use and Improved Outcomes by Implementation of an Algorithm-Based Clinical Guideline for Nonpurulent Skin and Soft Tissue Infections

    martes, febrero 18, 2020
    Author(s): John P Haran,Melissa Goulding,Maureen Campion,Gail Scully,Arnav Chandra,Rebecca Goldberg,Allyson Day,Emily McLendon,Melissa A Clark
    Source: Annals of emergency medicine
  • Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease

    viernes, diciembre 27, 2019
    Author(s): Troy W Whitfield,Debra A Ragland,Konstantin B Zeldovich,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir

    martes, diciembre 24, 2019
    Author(s): Jennifer Timm,Klajdi Kosovrasti,Mina Henes,Florian Leidner,Shurong Hou,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS chemical biology
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury

    viernes, septiembre 06, 2019
    Author(s): Sanda Win,Robert Wm Min,Christopher Q Chen,Jun Zhang,Yibu Chen,Meng Li,Ayako Suzuki,Manal F Abdelmalek,Ying Wang,Mariam Aghajan,Filbert Wm Aung,Anna Mae Diehl,Roger J Davis,Tin A Than,Neil Kaplowitz
    Source: The Journal of clinical investigation
  • Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

    jueves, agosto 29, 2019
    Author(s): Anne Margriet Heijink,Marieke Everts,Megan E Honeywell,Ryan Richards,Yannick P Kok,Elisabeth G E de Vries,Michael J Lee,Marcel A T M van Vugt
    Source: Cell reports
  • HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope

    miércoles, agosto 07, 2019
    Author(s): Linah N Rusere,Gordon J Lockbaum,Sook-Kyung Lee,Mina Henes,Klajdi Kosovrasti,Ean Spielvogel,Ellen A Nalivaika,Ronald Swanstrom,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance

    miércoles, julio 31, 2019
    Author(s): Mina Henes,Gordon J Lockbaum,Klajdi Kosovrasti,Florian Leidner,Gily S Nachum,Ellen A Nalivaika,Sook-Kyung Lee,Ean Spielvogel,Shuntai Zhou,Ronald Swanstrom,Daniel N A Bolon,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS chemical biology
  • Gut Colonization Preceding Mucosal Barrier Injury Bloodstream Infection in Pediatric Hematopoietic Stem Cell Transplantation Recipients

    lunes, julio 22, 2019
    Author(s): Matthew S Kelly,Doyle V Ward,Christopher J Severyn,Mehreen Arshad,Sarah M Heston,Kirsten Jenkins,Paul L Martin,Lauren McGill,Andre Stokhuyzen,Shakti K Bhattarai,Vanni Bucci,Patrick C Seed
    Source: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • The discontinuation of contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: Impact upon patient adverse events and hospital operations

    sábado, julio 20, 2019
    Author(s): Gregory M Schrank,Graham M Snyder,Roger B Davis,Westyn Branch-Elliman,Sharon B Wright
    Source: BMJ quality & safety
  • NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations

    viernes, junio 28, 2019
    Author(s): Rieko Ishima,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Journal of biomolecular NMR
  • Harnessing robotic automation and web-based technologies to modernize scientific outreach

    jueves, junio 27, 2019
    Author(s): Orna Dahan,Bat-Shahar Dorfman,Serkan Sayin,Brittany Rosener,Tiffany Hua,Anat Yarden,Amir Mitchell
    Source: PLoS biology
  • Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

    miércoles, mayo 01, 2019
    Author(s): M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,Carlos Escalante,Steven R Grossman
    Source: Molecular pharmacology
  • Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors

    sábado, marzo 02, 2019
    Author(s): Ayşegül Özen,Kristina Prachanronarong,Ashley N Matthew,Djade I Soumana,Celia A Schiffer
    Source: Critical reviews in biochemistry and molecular biology
  • Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease

    viernes, diciembre 14, 2018
    Author(s): Gordon J Lockbaum,Florian Leidner,Linah N Rusere,Mina Henes,Klajdi Kosovrasti,Gily S Nachum,Ellen A Nalivaika,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer
    Source: ACS infectious diseases
  • Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

    viernes, noviembre 02, 2018
    Author(s): Kristina L Prachanronarong,Aneth S Canale,Ping Liu,Mohan Somasundaran,Shurong Hou,Yu-Ping Poh,Thomas Han,Quan Zhu,Nicholas Renzette,Konstantin B Zeldovich,Timothy F Kowalik,Nese Kurt-Yilmaz,Jeffrey D Jensen,Daniel N A Bolon,Wayne A Marasco,Robert W Finberg,Celia A Schiffer,Jennifer P Wang
    Source: Journal of virology
  • A call to arms: Unifying the fight against resistance

    jueves, octubre 25, 2018
    Author(s): Alexis Kaushansky,Lizbeth Hedstrom,Aaron Goldman,Juswinder Singh,Priscilla L Yang,Pradipsinh K Rathod,Michael Cynamon,Dominik Wodarz,Daruka Mahadevan,Andrew Tomaras,Manuel A Navia,Celia A Schiffer
    Source: Science signaling
  • Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease

    martes, agosto 28, 2018
    Author(s): Ashley N Matthew,Florian Leidner,Alicia Newton,Christos J Petropoulos,Wei Huang,Akbar Ali,Nese KurtYilmaz,Celia A Schiffer
    Source: Structure (London, England : 1993)
  • Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells

    miércoles, agosto 08, 2018
    Author(s): Benjamin D Landry,Thomas Leete,Ryan Richards,Peter Cruz-Gordillo,Hannah R Schwartz,Megan E Honeywell,Gary Ren,Alyssa D Schwartz,Shelly R Peyton,Michael J Lee
    Source: Molecular systems biology
  • Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants

    martes, julio 24, 2018
    Author(s): Linah N Rusere,Ashley N Matthew,Gordon J Lockbaum,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt Yilmaz,Celia A Schiffer,Akbar Ali
    Source: ACS medicinal chemistry letters
  • Macrolide Resistance in Cases of Community-Acquired Bacterial Pneumonia in the Emergency Department

    jueves, mayo 24, 2018
    Author(s): John P Haran,Gregory A Volturo
    Source: The Journal of emergency medicine
  • Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease

    sábado, marzo 24, 2018
    Author(s): Florian Leidner,Nese Kurt Yilmaz,Janet Paulsen,Yves A Muller,Celia A Schiffer
    Source: Journal of chemical theory and computation
  • Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance

    martes, febrero 20, 2018
    Author(s): Shahid N Khan,John D Persons,Janet L Paulsen,Michel Guerrero,Celia A Schiffer,Nese Kurt-Yilmaz,Rieko Ishima
    Source: Biochemistry
  • Evolutionary mechanisms studied through protein fitness landscapes

    domingo, enero 21, 2018
    Author(s): Aneth S Canale,Pamela A Cote-Hammarlof,Julia M Flynn,Daniel Na Bolon
    Source: Current opinion in structural biology
  • Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

    sábado, diciembre 16, 2017
    Author(s): Jong Hun Kim,Eunjung Lee,Randall H Friedline,Sujin Suk,Dae Young Jung,Sezin Dagdeviren,Xiaodi Hu,Kunikazu Inashima,Hye Lim Noh,Jung Yeon Kwon,Aya Nambu,Jun R Huh,Myoung Sook Han,Roger J Davis,Amy S Lee,Ki Won Lee,Jason K Kim
    Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • Hepatic Dysfunction Caused by Consumption of a High-Fat Diet

    sábado, diciembre 16, 2017
    Author(s): Anthony R Soltis,Norman J Kennedy,Xiaofeng Xin,Feng Zhou,Scott B Ficarro,Yoon Sing Yap,Bryan J Matthews,Douglas A Lauffenburger,Forest M White,Jarrod A Marto,Roger J Davis,Ernest Fraenkel
    Source: Cell reports
  • CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

    domingo, octubre 29, 2017
    Author(s): Leyuan Ma,Jeffrey I Boucher,Janet Paulsen,Sebastian Matuszewski,Christopher A Eide,Jianhong Ou,Garrett Eickelberg,Richard D Press,Lihua Julie Zhu,Brian J Druker,Susan Branford,Scot A Wolfe,Jeffrey D Jensen,Celia A Schiffer,Michael R Green,Daniel N Bolon
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress

    jueves, septiembre 21, 2017
    Author(s): Shashi Kant,Claire L Standen,Caroline Morel,Dae Young Jung,Jason K Kim,Wojciech Swat,Richard A Flavell,Roger J Davis
    Source: Cell reports
  • The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

    viernes, septiembre 01, 2017
    Author(s): Louise Ormond,Ping Liu,Sebastian Matuszewski,Nicholas Renzette,Claudia Bank,Konstantin Zeldovich,Daniel N Bolon,Timothy F Kowalik,Robert W Finberg,Jeffrey D Jensen,Jennifer P Wang
    Source: Genome biology and evolution
  • Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes

    lunes, julio 17, 2017
    Author(s): Graham M Snyder,Sharon B Wright,Anne Smithey,Meir Mizrahi,Michelle Sheppard,Elizabeth B Hirsch,Ram Chuttani,Riley Heroux,David S Yassa,Lovisa B Olafsdottir,Roger B Davis,Jiannis Anastasiou,Vijay Bapat,Kiran Bidari,Douglas K Pleskow,Daniel Leffler,Benjamin Lane,Alice Chen,Howard S Gold,Anthony Bartley,Aleah D King,Mandeep S Sawhney
    Source: Gastroenterology
  • Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants

    viernes, junio 09, 2017
    Author(s): Ashley N Matthew,Jacqueto Zephyr,Caitlin J Hill,Muhammad Jahangir,Alicia Newton,Christos J Petropoulos,Wei Huang,Nese Kurt-Yilmaz,Celia A Schiffer,Akbar Ali
    Source: Journal of medicinal chemistry
  • Can a nanoparticle that mimics Salmonella effectively combat tumor chemotherapy resistance?

    miércoles, marzo 22, 2017
    Author(s): Regino Mercado-Lubo,Beth A McCormick
    Source: Nanomedicine (London, England)
  • An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

    domingo, agosto 28, 2016
    Author(s): Claudia Bank,Nicholas Renzette,Ping Liu,Sebastian Matuszewski,Hyunjin Shim,Matthieu Foll,Daniel N A Bolon,Konstantin B Zeldovich,Timothy F Kowalik,Robert W Finberg,Jennifer P Wang,Jeffrey D Jensen
    Source: Evolution; international journal of organic evolution
  • Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease

    viernes, agosto 12, 2016
    Author(s): Djadé I Soumana,Nese Kurt Yilmaz,Akbar Ali,Kristina L Prachanronarong,Celia A Schiffer
    Source: Journal of the American Chemical Society
  • A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

    martes, julio 26, 2016
    Author(s): Regino Mercado-Lubo,Yuanwei Zhang,Liang Zhao,Kyle Rossi,Xiang Wu,Yekui Zou,Antonio Castillo,Jack Leonard,Rita Bortell,Dale L Greiner,Leonard D Shultz,Gang Han,Beth A McCormick
    Source: Nature communications
  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    sábado, julio 23, 2016
    Author(s): Arnab Ray Chaudhuri,Elsa Callen,Xia Ding,Ewa Gogola,Alexandra A Duarte,Ji-Eun Lee,Nancy Wong,Vanessa Lafarga,Jennifer A Calvo,Nicholas J Panzarino,Sam John,Amanda Day,Anna Vidal Crespo,Binghui Shen,Linda M Starnes,Julian R de Ruiter,Jeremy A Daniel,Panagiotis A Konstantinopoulos,David Cortez,Sharon B Cantor,Oscar Fernandez-Capetillo,Kai Ge,Jos Jonkers,Sven Rottenberg,Shyam K Sharan,André Nussenzweig
    Source: Nature
  • HIV-1 capsid is involved in post-nuclear entry steps

    lunes, abril 25, 2016
    Author(s): Nan-Yu Chen,Lihong Zhou,Paul J Gane,Silvana Opp,Neil J Ball,Giuseppe Nicastro,Madeleine Zufferey,Cindy Buffone,Jeremy Luban,David Selwood,Felipe Diaz-Griffero,Ian Taylor,Ariberto Fassati
    Source: Retrovirology
  • Improving Viral Protease Inhibitors to Counter Drug Resistance

    miércoles, abril 20, 2016
    Author(s): Nese Kurt Yilmaz,Ronald Swanstrom,Celia A Schiffer
    Source: Trends in microbiology
  • Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

    martes, marzo 22, 2016
    Author(s): Doyle V Ward,Matthias Scholz,Moreno Zolfo,Diana H Taft,Kurt R Schibler,Adrian Tett,Nicola Segata,Ardythe L Morrow
    Source: Cell reports
  • Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

    martes, marzo 08, 2016
    Author(s): Santiago Vernia,Julie Cavanagh-Kyros,Tamera Barrett,Cathy Tournier,Roger J Davis
    Source: Cell reports
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    sábado, enero 23, 2016
    Author(s): Daniel J Klionsky,Kotb Abdelmohsen,Akihisa Abe,Md Joynal Abedin,Hagai Abeliovich,Abraham Acevedo Arozena,Hiroaki Adachi,Christopher M Adams,Peter D Adams,Khosrow Adeli,Peter J Adhihetty,Sharon G Adler,Galila Agam,Rajesh Agarwal,Manish K Aghi,Maria Agnello,Patrizia Agostinis,Patricia V Aguilar,Julio Aguirre-Ghiso,Edoardo M Airoldi,Slimane Ait-Si-Ali,Takahiko Akematsu,Emmanuel T Akporiaye,Mohamed Al-Rubeai,Guillermo M Albaiceta,Chris Albanese,Diego Albani,Matthew L Albert,Jesus Aldudo,Hana Algül,Mehrdad Alirezaei,Iraide Alloza,Alexandru Almasan,Maylin Almonte-Beceril,Emad S Alnemri,Covadonga Alonso,Nihal Altan-Bonnet,Dario C Altieri,Silvia Alvarez,Lydia Alvarez-Erviti,Sandro Alves,Giuseppina Amadoro,Atsuo Amano,Consuelo Amantini,Santiago Ambrosio,Ivano Amelio,Amal O Amer,Mohamed Amessou,Angelika Amon,Zhenyi An,Frank A Anania,Stig U Andersen,Usha P Andley,Catherine K Andreadi,Nathalie Andrieu-Abadie,Alberto Anel,David K Ann,Shailendra Anoopkumar-Dukie,Manuela 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Dash,Crispin R Dass,Hazel Marie Davey,Lester M Davids,David Dávila,Roger J Davis,Ted M Dawson,Valina L Dawson,Paula Daza,Jackie de Belleroche,Paul de Figueiredo,Regina Celia Bressan Queiroz de Figueiredo,José de la Fuente,Luisa De Martino,Antonella De Matteis,Guido Ry De Meyer,Angelo De Milito,Mauro De Santi,Wanderley de Souza,Vincenzo De Tata,Daniela De Zio,Jayanta Debnath,Reinhard Dechant,Jean-Paul Decuypere,Shane Deegan,Benjamin Dehay,Barbara Del Bello,Dominic P Del Re,Régis Delage-Mourroux,Lea Md Delbridge,Louise Deldicque,Elizabeth Delorme-Axford,Yizhen Deng,Joern Dengjel,Melanie Denizot,Paul Dent,Channing J Der,Vojo Deretic,Benoît Derrien,Eric Deutsch,Timothy P Devarenne,Rodney J Devenish,Sabrina Di Bartolomeo,Nicola Di Daniele,Fabio Di Domenico,Alessia Di Nardo,Simone Di Paola,Antonio Di Pietro,Livia Di Renzo,Aaron DiAntonio,Guillermo Díaz-Araya,Ines Díaz-Laviada,Maria T Diaz-Meco,Javier Diaz-Nido,Chad A Dickey,Robert C Dickson,Marc Diederich,Paul Digard,Ivan Dikic,Savithrama P Dinesh-Kumar,Chan Ding,Wen-Xing Ding,Zufeng Ding,Luciana Dini,Jörg Hw Distler,Abhinav Diwan,Mojgan Djavaheri-Mergny,Kostyantyn Dmytruk,Renwick Cj Dobson,Volker Doetsch,Karol Dokladny,Svetlana Dokudovskaya,Massimo Donadelli,X Charlie Dong,Xiaonan Dong,Zheng Dong,Terrence M Donohue,Kelly S Doran,Gabriella D'Orazi,Gerald W Dorn,Victor Dosenko,Sami Dridi,Liat Drucker,Jie Du,Li-Lin Du,Lihuan Du,André du Toit,Priyamvada Dua,Lei Duan,Pu Duann,Vikash Kumar Dubey,Michael R Duchen,Michel A Duchosal,Helene Duez,Isabelle Dugail,Verónica I Dumit,Mara C Duncan,Elaine A Dunlop,William A Dunn,Nicolas Dupont,Luc Dupuis,Raúl V Durán,Thomas M Durcan,Stéphane Duvezin-Caubet,Umamaheswar Duvvuri,Vinay Eapen,Darius Ebrahimi-Fakhari,Arnaud Echard,Leopold Eckhart,Charles L Edelstein,Aimee L Edinger,Ludwig Eichinger,Tobias Eisenberg,Avital Eisenberg-Lerner,N Tony Eissa,Wafik S El-Deiry,Victoria El-Khoury,Zvulun Elazar,Hagit Eldar-Finkelman,Chris Jh Elliott,Enzo Emanuele,Urban Emmenegger,Nikolai Engedal,Anna-Mart Engelbrecht,Simone Engelender,Jorrit M Enserink,Ralf Erdmann,Jekaterina Erenpreisa,Rajaraman Eri,Jason L Eriksen,Andreja Erman,Ricardo Escalante,Eeva-Liisa Eskelinen,Lucile Espert,Lorena Esteban-Martínez,Thomas J Evans,Mario Fabri,Gemma Fabrias,Cinzia Fabrizi,Antonio Facchiano,Nils J Færgeman,Alberto Faggioni,W Douglas Fairlie,Chunhai Fan,Daping Fan,Jie Fan,Shengyun Fang,Manolis Fanto,Alessandro Fanzani,Thomas Farkas,Mathias Faure,Francois B Favier,Howard Fearnhead,Massimo Federici,Erkang Fei,Tania C Felizardo,Hua Feng,Yibin Feng,Yuchen Feng,Thomas A Ferguson,Álvaro F Fernández,Maite G Fernandez-Barrena,Jose C Fernandez-Checa,Arsenio Fernández-López,Martin E Fernandez-Zapico,Olivier Feron,Elisabetta Ferraro,Carmen Veríssima Ferreira-Halder,Laszlo Fesus,Ralph Feuer,Fabienne C Fiesel,Eduardo C Filippi-Chiela,Giuseppe Filomeni,Gian Maria Fimia,John H Fingert,Steven Finkbeiner,Toren Finkel,Filomena Fiorito,Paul B Fisher,Marc Flajolet,Flavio Flamigni,Oliver Florey,Salvatore Florio,R Andres Floto,Marco Folini,Carlo Follo,Edward A Fon,Francesco Fornai,Franco Fortunato,Alessandro Fraldi,Rodrigo Franco,Arnaud Francois,Aurélie François,Lisa B Frankel,Iain Dc Fraser,Norbert Frey,Damien G Freyssenet,Christian Frezza,Scott L Friedman,Daniel E Frigo,Dongxu Fu,José M Fuentes,Juan Fueyo,Yoshio Fujitani,Yuuki Fujiwara,Mikihiro Fujiya,Mitsunori Fukuda,Simone Fulda,Carmela Fusco,Bozena Gabryel,Matthias Gaestel,Philippe Gailly,Malgorzata Gajewska,Sehamuddin Galadari,Gad Galili,Inmaculada Galindo,Maria F Galindo,Giovanna Galliciotti,Lorenzo Galluzzi,Luca Galluzzi,Vincent Galy,Noor Gammoh,Sam Gandy,Anand K Ganesan,Swamynathan Ganesan,Ian G Ganley,Monique Gannagé,Fen-Biao Gao,Feng Gao,Jian-Xin Gao,Lorena García Nannig,Eleonora García Véscovi,Marina Garcia-Macía,Carmen Garcia-Ruiz,Abhishek D Garg,Pramod Kumar Garg,Ricardo Gargini,Nils Christian Gassen,Damián Gatica,Evelina Gatti,Julie Gavard,Evripidis Gavathiotis,Liang Ge,Pengfei Ge,Shengfang Ge,Po-Wu Gean,Vania Gelmetti,Armando A Genazzani,Jiefei Geng,Pascal Genschik,Lisa Gerner,Jason E Gestwicki,David A Gewirtz,Saeid Ghavami,Eric Ghigo,Debabrata Ghosh,Anna Maria Giammarioli,Francesca Giampieri,Claudia Giampietri,Alexandra Giatromanolaki,Derrick J Gibbings,Lara Gibellini,Spencer B Gibson,Vanessa Ginet,Antonio Giordano,Flaviano Giorgini,Elisa Giovannetti,Stephen E Girardin,Suzana Gispert,Sandy Giuliano,Candece L Gladson,Alvaro Glavic,Martin Gleave,Nelly Godefroy,Robert M Gogal,Kuppan Gokulan,Gustavo H Goldman,Delia Goletti,Michael S Goligorsky,Aldrin V Gomes,Ligia C Gomes,Hernando Gomez,Candelaria Gomez-Manzano,Rubén Gómez-Sánchez,Dawit Ap Gonçalves,Ebru Goncu,Qingqiu Gong,Céline Gongora,Carlos B Gonzalez,Pedro Gonzalez-Alegre,Pilar Gonzalez-Cabo,Rosa Ana González-Polo,Ing Swie Goping,Carlos Gorbea,Nikolai V Gorbunov,Daphne R Goring,Adrienne M Gorman,Sharon M Gorski,Sandro Goruppi,Shino Goto-Yamada,Cecilia Gotor,Roberta A Gottlieb,Illana Gozes,Devrim Gozuacik,Yacine Graba,Martin Graef,Giovanna E Granato,Gary Dean Grant,Steven Grant,Giovanni Luca Gravina,Douglas R Green,Alexander Greenhough,Michael T Greenwood,Benedetto Grimaldi,Frédéric Gros,Charles Grose,Jean-Francois Groulx,Florian Gruber,Paolo Grumati,Tilman Grune,Jun-Lin Guan,Kun-Liang Guan,Barbara Guerra,Carlos Guillen,Kailash Gulshan,Jan Gunst,Chuanyong Guo,Lei Guo,Ming Guo,Wenjie Guo,Xu-Guang Guo,Andrea A Gust,Åsa B Gustafsson,Elaine Gutierrez,Maximiliano G Gutierrez,Ho-Shin Gwak,Albert Haas,James E Haber,Shinji Hadano,Monica Hagedorn,David R Hahn,Andrew J Halayko,Anne Hamacher-Brady,Kozo Hamada,Ahmed Hamai,Andrea Hamann,Maho Hamasaki,Isabelle Hamer,Qutayba Hamid,Ester M Hammond,Feng Han,Weidong Han,James T Handa,John A Hanover,Malene Hansen,Masaru Harada,Ljubica Harhaji-Trajkovic,J Wade Harper,Abdel Halim Harrath,Adrian L Harris,James Harris,Udo Hasler,Peter Hasselblatt,Kazuhisa Hasui,Robert G Hawley,Teresa S Hawley,Congcong He,Cynthia Y He,Fengtian He,Gu He,Rong-Rong He,Xian-Hui He,You-Wen He,Yu-Ying He,Joan K Heath,Marie-Josée Hébert,Robert A Heinzen,Gudmundur Vignir Helgason,Michael Hensel,Elizabeth P Henske,Chengtao Her,Paul K Herman,Agustín Hernández,Carlos Hernandez,Sonia Hernández-Tiedra,Claudio Hetz,P Robin Hiesinger,Katsumi Higaki,Sabine Hilfiker,Bradford G Hill,Joseph A Hill,William D Hill,Keisuke Hino,Daniel Hofius,Paul Hofman,Günter U Höglinger,Jörg Höhfeld,Marina K Holz,Yonggeun Hong,David A Hood,Jeroen Jm Hoozemans,Thorsten Hoppe,Chin Hsu,Chin-Yuan Hsu,Li-Chung Hsu,Dong Hu,Guochang Hu,Hong-Ming Hu,Hongbo Hu,Ming Chang Hu,Yu-Chen Hu,Zhuo-Wei Hu,Fang Hua,Ya Hua,Canhua Huang,Huey-Lan Huang,Kuo-How Huang,Kuo-Yang Huang,Shile Huang,Shiqian Huang,Wei-Pang Huang,Yi-Ran Huang,Yong Huang,Yunfei Huang,Tobias B Huber,Patricia Huebbe,Won-Ki Huh,Juha J Hulmi,Gang Min Hur,James H Hurley,Zvenyslava Husak,Sabah Na Hussain,Salik Hussain,Jung Jin Hwang,Seungmin Hwang,Thomas Is Hwang,Atsuhiro Ichihara,Yuzuru Imai,Carol Imbriano,Megumi Inomata,Takeshi Into,Valentina Iovane,Juan L Iovanna,Renato V Iozzo,Nancy Y Ip,Javier E Irazoqui,Pablo Iribarren,Yoshitaka Isaka,Aleksandra J Isakovic,Harry Ischiropoulos,Jeffrey S Isenberg,Mohammad Ishaq,Hiroyuki Ishida,Isao Ishii,Jane E Ishmael,Ciro Isidoro,Ken-Ichi Isobe,Erika Isono,Shohreh Issazadeh-Navikas,Koji Itahana,Eisuke Itakura,Andrei I Ivanov,Anand Krishnan V Iyer,José M Izquierdo,Yotaro Izumi,Valentina Izzo,Marja Jäättelä,Nadia Jaber,Daniel John Jackson,William T Jackson,Tony George Jacob,Thomas S Jacques,Chinnaswamy Jagannath,Ashish Jain,Nihar Ranjan Jana,Byoung Kuk Jang,Alkesh Jani,Bassam Janji,Paulo Roberto Jannig,Patric J Jansson,Steve Jean,Marina Jendrach,Ju-Hong Jeon,Niels Jessen,Eui-Bae Jeung,Kailiang Jia,Lijun Jia,Hong Jiang,Hongchi Jiang,Liwen Jiang,Teng Jiang,Xiaoyan Jiang,Xuejun Jiang,Xuejun Jiang,Ying Jiang,Yongjun Jiang,Alberto Jiménez,Cheng Jin,Hongchuan Jin,Lei Jin,Meiyan Jin,Shengkan Jin,Umesh Kumar Jinwal,Eun-Kyeong Jo,Terje Johansen,Daniel E Johnson,Gail Vw Johnson,James D Johnson,Eric Jonasch,Chris 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Khandelwal,Sangeeta Khare,Juliann G Kiang,Amy A Kiger,Akio Kihara,Arianna L Kim,Cheol Hyeon Kim,Deok Ryong Kim,Do-Hyung Kim,Eung Kweon Kim,Hye Young Kim,Hyung-Ryong Kim,Jae-Sung Kim,Jeong Hun Kim,Jin Cheon Kim,Jin Hyoung Kim,Kwang Woon Kim,Michael D Kim,Moon-Moo Kim,Peter K Kim,Seong Who Kim,Soo-Youl Kim,Yong-Sun Kim,Yonghyun Kim,Adi Kimchi,Alec C Kimmelman,Tomonori Kimura,Jason S King,Karla Kirkegaard,Vladimir Kirkin,Lorrie A Kirshenbaum,Shuji Kishi,Yasuo Kitajima,Katsuhiko Kitamoto,Yasushi Kitaoka,Kaio Kitazato,Rudolf A Kley,Walter T Klimecki,Michael Klinkenberg,Jochen Klucken,Helene Knævelsrud,Erwin Knecht,Laura Knuppertz,Jiunn-Liang Ko,Satoru Kobayashi,Jan C Koch,Christelle Koechlin-Ramonatxo,Ulrich Koenig,Young Ho Koh,Katja Köhler,Sepp D Kohlwein,Masato Koike,Masaaki Komatsu,Eiki Kominami,Dexin Kong,Hee Jeong Kong,Eumorphia G Konstantakou,Benjamin T Kopp,Tamas Korcsmaros,Laura Korhonen,Viktor I Korolchuk,Nadya V Koshkina,Yanjun Kou,Michael I Koukourakis,Constantinos Koumenis,Attila L Kovács,Tibor Kovács,Werner J Kovacs,Daisuke Koya,Claudine Kraft,Dimitri Krainc,Helmut Kramer,Tamara Kravic-Stevovic,Wilhelm Krek,Carole Kretz-Remy,Roswitha Krick,Malathi Krishnamurthy,Janos Kriston-Vizi,Guido Kroemer,Michael C Kruer,Rejko Kruger,Nicholas T Ktistakis,Kazuyuki Kuchitsu,Christian Kuhn,Addanki Pratap Kumar,Anuj Kumar,Ashok Kumar,Deepak Kumar,Dhiraj Kumar,Rakesh Kumar,Sharad Kumar,Mondira Kundu,Hsing-Jien Kung,Atsushi Kuno,Sheng-Han Kuo,Jeff Kuret,Tino Kurz,Terry Kwok,Taeg Kyu Kwon,Yong Tae Kwon,Irene Kyrmizi,Albert R La Spada,Frank Lafont,Tim Lahm,Aparna Lakkaraju,Truong Lam,Trond Lamark,Steve Lancel,Terry H Landowski,Darius J R Lane,Jon D Lane,Cinzia Lanzi,Pierre Lapaquette,Louis R Lapierre,Jocelyn Laporte,Johanna Laukkarinen,Gordon W Laurie,Sergio Lavandero,Lena Lavie,Matthew J LaVoie,Betty Yuen Kwan Law,Helen Ka-Wai Law,Kelsey B Law,Robert Layfield,Pedro A Lazo,Laurent Le Cam,Karine G Le Roch,Hervé Le Stunff,Vijittra Leardkamolkarn,Marc 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    Source: Autophagy
  • A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

    martes, diciembre 15, 2015
    Author(s): Li Jiang,Ping Liu,Claudia Bank,Nicholas Renzette,Kristina Prachanronarong,Lutfu S Yilmaz,Daniel R Caffrey,Konstantin B Zeldovich,Celia A Schiffer,Timothy F Kowalik,Jeffrey D Jensen,Robert W Finberg,Jennifer P Wang,Daniel N A Bolon
    Source: Journal of molecular biology
  • Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia

    miércoles, octubre 28, 2015
    Author(s): Megan K Proulx,Samantha G Palace,Sumanth Gandra,Brenda Torres,Susan Weir,Tracy Stiles,Richard T Ellison,Jon D Goguen
    Source: The Journal of infectious diseases
  • Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy

    martes, mayo 12, 2015
    Author(s): Jean Ndjomou,M Josie Corby,Noreena L Sweeney,Alicia M Hanson,Cihan Aydin,Akbar Ali,Celia A Schiffer,Kelin Li,Kevin J Frankowski,Frank J Schoenen,David N Frick
    Source: ACS chemical biology
  • Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5

    jueves, abril 30, 2015
    Author(s): Yongliang Zhang,Thang Nguyen,Peng Tang,Norman J Kennedy,Huipeng Jiao,Mingliang Zhang,Joseph M Reynolds,Anja Jaeschke,Natalia Martin-Orozco,Yeonseok Chung,Wei-min He,Chen Wang,Weiping Jia,Baoxue Ge,Roger J Davis,Richard A Flavell,Chen Dong
    Source: The Journal of biological chemistry
  • Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy

    martes, marzo 10, 2015
    Author(s): Michael J Lee
    Source: Molecular cell
  • Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4

    jueves, marzo 05, 2015
    Author(s): Shawna Guillemette,Ryan W Serra,Min Peng,Janelle A Hayes,Panagiotis A Konstantinopoulos,Michael R Green,Sharon B Cantor
    Source: Genes & development
  • Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

    martes, febrero 17, 2015
    Author(s): Nevra Özer,Ayşegül Özen,Celia A Schiffer,Türkan Haliloğlu
    Source: Evolutionary applications
  • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

    martes, febrero 10, 2015
    Author(s): Rachel J Perry,João-Paulo G Camporez,Romy Kursawe,Paul M Titchenell,Dongyan Zhang,Curtis J Perry,Michael J Jurczak,Abulizi Abudukadier,Myoung Sook Han,Xian-Man Zhang,Hai-Bin Ruan,Xiaoyong Yang,Sonia Caprio,Susan M Kaech,Hei Sook Sul,Morris J Birnbaum,Roger J Davis,Gary W Cline,Kitt Falk Petersen,Gerald I Shulman
    Source: Cell
  • Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease

    viernes, octubre 31, 2014
    Author(s): Ayşegül Özen,Kuan-Hung Lin,Nese Kurt Yilmaz,Celia A Schiffer
    Source: Proceedings of the National Academy of Sciences of the United States of America
  • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

    jueves, octubre 23, 2014
    Author(s): Charlie G Buffie,Vanni Bucci,Richard R Stein,Peter T McKenney,Lilan Ling,Asia Gobourne,Daniel No,Hui Liu,Melissa Kinnebrew,Agnes Viale,Eric Littmann,Marcel R M van den Brink,Robert R Jenq,Ying Taur,Chris Sander,Justin R Cross,Nora C Toussaint,Joao B Xavier,Eric G Pamer
    Source: Nature
  • Structural analysis of asunaprevir resistance in HCV NS3/4A protease

    martes, septiembre 23, 2014
    Author(s): Djadé I Soumana,Akbar Ali,Celia A Schiffer
    Source: ACS chemical biology
  • Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

    miércoles, agosto 20, 2014
    Author(s): Yufeng Cai,Wazo Myint,Janet L Paulsen,Celia A Schiffer,Rieko Ishima,Nese Kurt Yilmaz
    Source: Journal of chemical theory and computation
  • Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease

    miércoles, agosto 06, 2014
    Author(s): Debra A Ragland,Ellen A Nalivaika,Madhavi N L Nalam,Kristina L Prachanronarong,Hong Cao,Rajintha M Bandaranayake,Yufeng Cai,Nese Kurt-Yilmaz,Celia A Schiffer
    Source: Journal of the American Chemical Society
  • The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway

    martes, julio 22, 2014
    Author(s): Santiago Vernia,Julie Cavanagh-Kyros,Luisa Garcia-Haro,Guadalupe Sabio,Tamera Barrett,Dae Young Jung,Jason K Kim,Jia Xu,Hennady P Shulha,Manuel Garber,Guangping Gao,Roger J Davis
    Source: Cell metabolism
  • Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses

    viernes, junio 27, 2014
    Author(s): Min Peng,Jenny Xie,Anna Ucher,Janet Stavnezer,Sharon B Cantor
    Source: The EMBO journal
  • Standardized metadata for human pathogen/vector genomic sequences

    miércoles, junio 18, 2014
    Author(s): Vivien G Dugan,Scott J Emrich,Gloria I Giraldo-Calderón,Omar S Harb,Ruchi M Newman,Brett E Pickett,Lynn M Schriml,Timothy B Stockwell,Christian J Stoeckert,Dan E Sullivan,Indresh Singh,Doyle V Ward,Alison Yao,Jie Zheng,Tanya Barrett,Bruce Birren,Lauren Brinkac,Vincent M Bruno,Elizabet Caler,Sinéad Chapman,Frank H Collins,Christina A Cuomo,Valentina Di Francesco,Scott Durkin,Mark Eppinger,Michael Feldgarden,Claire Fraser,W Florian Fricke,Maria Giovanni,Matthew R Henn,Erin Hine,Julie Dunning Hotopp,Ilene Karsch-Mizrachi,Jessica C Kissinger,Eun Mi Lee,Punam Mathur,Emmanuel F Mongodin,Cheryl I Murphy,Garry Myers,Daniel E Neafsey,Karen E Nelson,William C Nierman,Julia Puzak,David Rasko,David S Roos,Lisa Sadzewicz,Joana C Silva,Bruno Sobral,R Burke Squires,Rick L Stevens,Luke Tallon,Herve Tettelin,David Wentworth,Owen White,Rebecca Will,Jennifer Wortman,Yun Zhang,Richard H Scheuermann
    Source: PloS one
  • HIV-1 protease-substrate coevolution in nelfinavir resistance

    viernes, abril 11, 2014
    Author(s): Madhavi Kolli,Ayşegül Ozen,Nese Kurt-Yilmaz,Celia A Schiffer
    Source: Journal of virology
  • Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design

    martes, marzo 04, 2014
    Author(s): Ayşegül Ozen,Woody Sherman,Celia A Schiffer
    Source: Journal of chemical theory and computation