Research focus: Innate Immune Molecular Immunology 

• New regulators of Inflammasome biology and cell death 
• Metabolic regulators of Innate immunity 
• Function and regulation of tissue resident macrophages 
• Therapeutic targeting of innate immune signaling pathways

Representative publications

• Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 Sep 25;369(6511):1633-1637. 
  
  
• Humphries F, Shmuel-Galia L, Jiang Z, Wilson R, Landis P, Ng SL, Parsi KM, Maehr R, Cruz J, Morales-Ramos A, Ramanjulu JM, Bertin J, Pesiridis GS, Fitzgerald KA. A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol. 2021 May 18;6(59):eabi9002.
  
  
• Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells. Immunity. 2021 Jun 8;54(6):1137-1153.e8. 
  
  

More Publications

Join our Lab

The Humphries Lab is currently recruiting a post-doctoral fellow. If you are interested in joining our lab, please send a cover letter, CV, and contact information for three references to Dr. Fiachra Humphries.