Research Focus: 

• Atrial fibrillation: invention of test model, identification of disease mechanism, development of novel therapies in preclinical and clinical studies.
• Ventricular tachycardia after heart attack: invention of test model, identification of mechanism and development of diagnostics and therapies in preclinical studies.
• Cardiac gene delivery: invention of methods including virus and promoter modifications, atrial and whole heart gene painting and intravascular perfusion.

Representative Publications

• Kelemen K., Greener I.D., Wan X., Parajuli S., Donahue J.K. Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar. Nature Commun 2022;11:830. PMC8837660.
  
  
• Liu Z., Hutt J.A., Rajeshkumar B., Azuma Y., Duan K.L., Donahue J.K. Preclinical efficacy and safety of KCNH2-G628S gene therapy for post-operative atrial fibrillation. J Thorac Cardiovasc Surg 2017;154:1644-51. PMC6450389.
  
  
• Igarashi T., Finet J.E., Takeuchi A., Fujino Y., Strom M., Greener I.D., Rosenbaum D.S., Donahue J.K. Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation. Circulation 2012;125:216-25. PMC3260348.
  
  
• Sasano T., Kikuchi K., McDonald A., Donahue J.K. Molecular ablation of ventricular tachycardia after myocardial infarction.  Nature Medicine 2006;12:1256-8. PMC1783685.
  
  
• Donahue J.K.*, Heldman A.H., Fraser H., McDonald A.D., Miller J.M., Rade J.J., Eschenhagen T. and Marbán E. Focal modification of electrical conduction in the heart by viral gene transfer. Nature Medicine 2000;6:1395-1398. PMID 11100126.
  
  

More Publications

Join our Team

We are currently seeking qualified candidates for graduate student and post-doctoral research positions. If you are interested, please send a cover letter and CV to Dr. Kevin Donahue.