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Publications
Total:
displaying 0 out of
50
results
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
jueves, marzo 21, 2024
Author(s):
Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sena-Esteves,Jeffrey A Nickerson,Cathleen Lutz,William C Skarnes,Elaine T Lim,Dorothy P Schafer,Francesca Massi,John E Landers,Daryl A Bosco
Source:
Nature communications
Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
jueves, diciembre 21, 2023
Author(s):
Elif O Dogan,James Bouley,Jianjun Zhong,Ashley L Harkins,Allison M Keeler,Daryl A Bosco,Robert H Brown,Nils Henninger
Source:
Acta neuropathologica communications
Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
martes, agosto 01, 2023
Author(s):
Aydan Kahriman,James Bouley,Idil Tuncali,Elif O Dogan,Mariana Pereira,Thuyvan Luu,Daryl A Bosco,Samer Jaber,Owen M Peters,Robert H Brown,Nils Henninger
Source:
Brain : a journal of neurology
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
lunes, julio 03, 2023
Author(s):
Salome Funes,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,Jonathan Jung,None Shankaracharya,Matthew Unger,Debra Cameron,Pepper Dawes,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sena-Esteves,Cathleen Lutz,William C Skarnes,Elaine T Lim,Dorothy P Schafer,Francesca Massi,John E Landers,Daryl A Bosco
Source:
bioRxiv : the preprint server for biology
Intravital Imaging of Fluorescent Protein Expression in Mice with a Closed-Skull Traumatic Brain Injury and Cranial Window Using a Two-Photon Microscope
lunes, mayo 08, 2023
Author(s):
Jianjun Zhong,Georgia Gunner,Nils Henninger,Dorothy P Schafer,Daryl A Bosco
Source:
Journal of visualized experiments : JoVE
Interactions between FUS and the C-terminal Domain of Nup62 are Sufficient for their Co-phase Separation into Amorphous Assemblies
lunes, enero 23, 2023
Author(s):
Meenakshi Sundaram Kumar,Karly M Stallworth,Anastasia C Murthy,Su Min Lim,Nan Li,Aastha Jain,James B Munro,Nicolas L Fawzi,Clotilde Lagier-Tourenne,Daryl A Bosco
Source:
Journal of molecular biology
Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons
viernes, diciembre 23, 2022
Author(s):
Meenakshi Sundaram Kumar,Megan E Fowler-Magaw,Daniel Kulick,Sivakumar Boopathy,Del Hayden Gadd,Melissa Rotunno,Catherine Douthwright,Diane Golebiowski,Issa Yusuf,Zuoshang Xu,Robert H Brown,Miguel Sena-Esteves,Alison L O'Neil,Daryl A Bosco
Source:
International journal of molecular sciences
A reference human induced pluripotent stem cell line for large-scale collaborative studies
viernes, diciembre 02, 2022
Author(s):
Caroline B Pantazis,Andrian Yang,Erika Lara,Justin A McDonough,Cornelis Blauwendraat,Lirong Peng,Hideyuki Oguro,Jitendra Kanaujiya,Jizhong Zou,David Sebesta,Gretchen Pratt,Erin Cross,Jeffrey Blockwick,Philip Buxton,Lauren Kinner-Bibeau,Constance Medura,Christopher Tompkins,Stephen Hughes,Marianita Santiana,Faraz Faghri,Mike A Nalls,Daniel Vitale,Shannon Ballard,Yue A Qi,Daniel M Ramos,Kailyn M Anderson,Julia Stadler,Priyanka Narayan,Jason Papademetriou,Luke Reilly,Matthew P Nelson,Sanya Aggarwal,Leah U Rosen,Peter Kirwan,Venkat Pisupati,Steven L Coon,Sonja W Scholz,Theresa Priebe,Miriam Öttl,Jian Dong,Marieke Meijer,Lara J M Janssen,Vanessa S Lourenco,Rik van der Kant,Dennis Crusius,Dominik Paquet,Ana-Caroline Raulin,Guojun Bu,Aaron Held,Brian J Wainger,Rebecca M C Gabriele,Jackie M Casey,Selina Wray,Dad Abu-Bonsrah,Clare L Parish,Melinda S Beccari,Don W Cleveland,Emmy Li,Indigo V L Rose,Martin Kampmann,Carles Calatayud Aristoy,Patrik Verstreken,Laurin Heinrich,Max Y Chen,Birgitt Schüle,Dan Dou,Erika L F Holzbaur,Maria Clara Zanellati,Richa Basundra,Mohanish Deshmukh,Sarah Cohen,Richa Khanna,Malavika Raman,Zachary S Nevin,Madeline Matia,Jonas Van Lent,Vincent Timmerman,Bruce R Conklin,Katherine Johnson Chase,Ke Zhang,Salome Funes,Daryl A Bosco,Lena Erlebach,Marc Welzer,Deborah Kronenberg-Versteeg,Guochang Lyu,Ernest Arenas,Elena Coccia,Lily Sarrafha,Tim Ahfeldt,John C Marioni,William C Skarnes,Mark R Cookson,Michael E Ward,Florian T Merkle
Source:
Cell stem cell
Human Microglia-like Cells: Differentiation from Induced Pluripotent Stem Cells and In Vitro Live-cell Phagocytosis Assay using Human Synaptosomes
lunes, septiembre 05, 2022
Author(s):
Salome Funes,Daryl A Bosco
Source:
Journal of visualized experiments : JoVE
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons
viernes, marzo 11, 2022
Author(s):
Cristian Arredondo,Carolina Cefaliello,Agnieszka Dyrda,Nur Jury,Pablo Martinez,Iván Díaz,Armando Amaro,Helene Tran,Danna Morales,Maria Pertusa,Lorelei Stoica,Elsa Fritz,Daniela Corvalán,Sebastián Abarzúa,Maxs Méndez-Ruette,Paola Fernández,Fabiola Rojas,Meenakshi Sundaram Kumar,Rodrigo Aguilar,Sandra Almeida,Alexandra Weiss,Fernando J Bustos,Fernando González-Nilo,Carolina Otero,Maria Florencia Tevy,Daryl A Bosco,Juan C Sáez,Thilo Kähne,Fen-Biao Gao,James D Berry,Katharine Nicholson,Miguel Sena-Esteves,Rodolfo Madrid,Diego Varela,Martin Montecino,Robert H Brown,Brigitte van Zundert
Source:
Neuron
Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury
sábado, enero 01, 2022
Author(s):
Aydan Kahriman,James Bouley,Daryl A Bosco,Mohammed Salman Shazeeb,Nils Henninger
Source:
Neuroscience letters
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
miércoles, junio 30, 2021
Author(s):
Aydan Kahriman,James Bouley,Thomas W Smith,Daryl A Bosco,Amanda L Woerman,Nils Henninger
Source:
Acta neuropathologica communications
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization
miércoles, junio 02, 2021
Author(s):
Eric J Schmidt,Salome Funes,Jeanne E McKeon,Brittany R Morgan,Sivakumar Boopathy,Lauren C O'Connor,Osman Bilsel,Francesca Massi,Antoine Jégou,Daryl A Bosco
Source:
Proceedings of the National Academy of Sciences of the United States of America
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway
martes, junio 01, 2021
Author(s):
Yen-Chen Lin,Meenakshi Sundaram Kumar,Nandini Ramesh,Eric N Anderson,Aivi T Nguyen,Boram Kim,Simon Cheung,Justin A McDonough,William C Skarnes,Rodrigo Lopez-Gonzalez,John E Landers,Nicolas L Fawzi,Ian R A Mackenzie,Edward B Lee,Jeffrey A Nickerson,David Grunwald,Udai B Pandey,Daryl A Bosco
Source:
Nature neuroscience
Is the primate-specific protein pLG72 affecting SOD1 functionality and superoxide formation?
martes, julio 07, 2020
Author(s):
Giulia Murtas,Silvia Sacchi,Meenakshi Sundaram Kumar,Daryl A Bosco,Loredano Pollegioni
Source:
Free radical research
Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction
viernes, octubre 18, 2019
Author(s):
Mathieu Bartoletti,Daryl A Bosco,Sandrine Da Cruz,Clotilde Lagier-Tourenne,Nicole Liachko,Sebastian Markmiller,Kristin M Webster,Kristi A Wharton
Source:
The Journal of neuroscience : the official journal of the Society for Neuroscience
The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing
viernes, mayo 17, 2019
Author(s):
Maeve Tischbein,Desiree M Baron,Yen-Chen Lin,Katherine V Gall,John E Landers,Claudia Fallini,Daryl A Bosco
Source:
The Journal of biological chemistry
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS
miércoles, febrero 27, 2019
Author(s):
Desiree M Baron,Tyler Matheny,Yen-Chen Lin,John D Leszyk,Kevin Kenna,Katherine V Gall,David P Santos,Maeve Tischbein,Salome Funes,Lawrence J Hayward,Evangelos Kiskinis,John E Landers,Roy Parker,Scott A Shaffer,Daryl A Bosco
Source:
Human molecular genetics
Translation dysregulation in neurodegenerative disorders
martes, diciembre 04, 2018
Author(s):
Daryl A Bosco
Source:
Proceedings of the National Academy of Sciences of the United States of America
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
miércoles, julio 25, 2018
Author(s):
Danilo B Medinas,Pablo Rozas,Francisca Martínez Traub,Ute Woehlbier,Robert H Brown,Daryl A Bosco,Claudio Hetz
Source:
Proceedings of the National Academy of Sciences of the United States of America
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation
viernes, marzo 10, 2017
Author(s):
Reddy Ranjith K Sama,Claudia Fallini,Rodolfo Gatto,Jeanne E McKeon,Yuyu Song,Melissa S Rotunno,Saul Penaranda,Izrail Abdurakhmanov,John E Landers,Gerardo Morfini,Scott T Brady,Daryl A Bosco
Source:
Scientific reports
Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice
domingo, diciembre 06, 2015
Author(s):
Owen M Peters,Gabriela Toro Cabrera,Helene Tran,Tania F Gendron,Jeanne E McKeon,Jake Metterville,Alexandra Weiss,Nicholas Wightman,Johnny Salameh,Juyhun Kim,Huaming Sun,Kevin B Boylan,Dennis Dickson,Zack Kennedy,Ziqiang Lin,Yong-Jie Zhang,Lillian Daughrity,Chris Jung,Fen-Biao Gao,Peter C Sapp,H Robert Horvitz,Daryl A Bosco,Solange P Brown,Pieter de Jong,Leonard Petrucelli,Chris Mueller,Robert H Brown
Source:
Neuron
Structural basis for mutation-induced destabilization of profilin 1 in ALS
miércoles, junio 10, 2015
Author(s):
Sivakumar Boopathy,Tania V Silvas,Maeve Tischbein,Silvia Jansen,Shivender M Shandilya,Jill A Zitzewitz,John E Landers,Bruce L Goode,Celia A Schiffer,Daryl A Bosco
Source:
Proceedings of the National Academy of Sciences of the United States of America
Autophagy meets fused in sarcoma-positive stress granules
miércoles, diciembre 03, 2014
Author(s):
Soledad Matus,Daryl A Bosco,Claudio Hetz
Source:
Neurobiology of aging
Functions of FUS/TLS from DNA repair to stress response: implications for ALS
miércoles, octubre 08, 2014
Author(s):
Reddy Ranjith Kumar Sama,Catherine L Ward,Daryl A Bosco
Source:
ASN neuro
Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis
viernes, agosto 29, 2014
Author(s):
Melissa S Rotunno,Jared R Auclair,Stephanie Maniatis,Scott A Shaffer,Jeffrey Agar,Daryl A Bosco
Source:
The Journal of biological chemistry
Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation
martes, marzo 18, 2014
Author(s):
Jared R Auclair,Joseph P Salisbury,Joshua L Johnson,Gregory A Petsko,Dagmar Ringe,Daryl A Bosco,Nathalie Y R Agar,Sandro Santagata,Heather D Durham,Jeffrey N Agar
Source:
Proteomics
An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis
miércoles, enero 01, 2014
Author(s):
Melissa S Rotunno,Daryl A Bosco
Source:
Frontiers in cellular neuroscience
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
sábado, octubre 05, 2013
Author(s):
Desiree M Baron,Laura J Kaushansky,Catherine L Ward,Reddy Ranjith K Sama,Ru-Ju Chian,Kristin J Boggio,Alexandre J C Quaresma,Jeffrey A Nickerson,Daryl A Bosco
Source:
Molecular neurodegeneration
Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage
sábado, agosto 10, 2013
Author(s):
Jared R Auclair,Joshua L Johnson,Qian Liu,Joseph P Salisbury,Melissa S Rotunno,Gregory A Petsko,Dagmar Ringe,Robert H Brown,Daryl A Bosco,Jeffrey N Agar
Source:
Biochemistry
Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase
miércoles, junio 19, 2013
Author(s):
Gerardo A Morfini,Daryl A Bosco,Hannah Brown,Rodolfo Gatto,Agnieszka Kaminska,Yuyu Song,Linda Molla,Lisa Baker,M Natalia Marangoni,Sarah Berth,Ehsan Tavassoli,Carolina Bagnato,Ashutosh Tiwari,Lawrence J Hayward,Gustavo F Pigino,D Martin Watterson,Chun-Fang Huang,Gary Banker,Robert H Brown,Scott T Brady
Source:
PloS one
FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
martes, abril 30, 2013
Author(s):
Reddy Ranjith K Sama,Catherine L Ward,Laura J Kaushansky,Nathan Lemay,Shinsuke Ishigaki,Fumihiko Urano,Daryl A Bosco
Source:
Journal of cellular physiology
Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1
jueves, abril 25, 2013
Author(s):
Teresa J Broering,Hongyan Wang,Naomi K Boatright,Yang Wang,Katherine Baptista,Gilda Shayan,Kerry A Garrity,Can Kayatekin,Daryl A Bosco,C Robert Matthews,Donna M Ambrosino,Zuoshang Xu,Gregory J Babcock
Source:
PloS one
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
miércoles, julio 18, 2012
Author(s):
Chi-Hong Wu,Claudia Fallini,Nicola Ticozzi,Pamela J Keagle,Peter C Sapp,Katarzyna Piotrowska,Patrick Lowe,Max Koppers,Diane McKenna-Yasek,Desiree M Baron,Jason E Kost,Paloma Gonzalez-Perez,Andrew D Fox,Jenni Adams,Franco Taroni,Cinzia Tiloca,Ashley Lyn Leclerc,Shawn C Chafe,Dev Mangroo,Melissa J Moore,Jill A Zitzewitz,Zuo-Shang Xu,Leonard H van den Berg,Jonathan D Glass,Gabriele Siciliano,Elizabeth T Cirulli,David B Goldstein,Francois Salachas,Vincent Meininger,Wilfried Rossoll,Antonia Ratti,Cinzia Gellera,Daryl A Bosco,Gary J Bassell,Vincenzo Silani,Vivian E Drory,Robert H Brown,John E Landers
Source:
Nature
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
jueves, marzo 15, 2012
Author(s):
Stefania Guareschi,Emanuela Cova,Cristina Cereda,Mauro Ceroni,Elena Donetti,Daryl A Bosco,Davide Trotti,Piera Pasinelli
Source:
Proceedings of the National Academy of Sciences of the United States of America
Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
miércoles, octubre 26, 2011
Author(s):
Marka van Blitterswijk,Sunita Gulati,Elizabeth Smoot,Matthew Jaffa,Nancy Maher,Bradley T Hyman,Adrian J Ivinson,Clemens R Scherzer,David A Schoenfeld,Merit E Cudkowicz,Robert H Brown,Daryl A Bosco
Source:
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis
miércoles, agosto 17, 2011
Author(s):
Daryl A Bosco,Matthew J LaVoie,Gregory A Petsko,Dagmar Ringe
Source:
Cold Spring Harbor perspectives in biology
A yeast model of FUS/TLS-dependent cytotoxicity
jueves, mayo 05, 2011
Author(s):
Shulin Ju,Daniel F Tardiff,Haesun Han,Kanneganti Divya,Quan Zhong,Lynne E Maquat,Daryl A Bosco,Lawrence J Hayward,Robert H Brown,Susan Lindquist,Dagmar Ringe,Gregory A Petsko
Source:
PLoS biology
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
martes, octubre 19, 2010
Author(s):
Daryl A Bosco,Gerardo Morfini,N Murat Karabacak,Yuyu Song,Francois Gros-Louis,Piera Pasinelli,Holly Goolsby,Benjamin A Fontaine,Nathan Lemay,Diane McKenna-Yasek,Matthew P Frosch,Jeffrey N Agar,Jean-Pierre Julien,Scott T Brady,Robert H Brown
Source:
Nature neuroscience
Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
viernes, octubre 15, 2010
Author(s):
Daryl A Bosco,John E Landers
Source:
CNS & neurological disorders drug targets
Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR
martes, agosto 17, 2010
Author(s):
Daryl A Bosco,Elan Zohar Eisenmesser,Michael W Clarkson,Magnus Wolf-Watz,Wladimir Labeikovsky,Oscar Millet,Dorothee Kern
Source:
Journal of molecular biology
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
jueves, agosto 12, 2010
Author(s):
Daryl A Bosco,Nathan Lemay,Hae Kyung Ko,Hongru Zhou,Chris Burke,Thomas J Kwiatkowski,Peter Sapp,Diane McKenna-Yasek,Robert H Brown,Lawrence J Hayward
Source:
Human molecular genetics
Paraoxonase gene mutations in amyotrophic lateral sclerosis
martes, junio 29, 2010
Author(s):
Nicola Ticozzi,Ashley Lyn LeClerc,Pamela J Keagle,Jonathan D Glass,Anne-Marie Wills,Marka van Blitterswijk,Daryl A Bosco,Ildefonso Rodriguez-Leyva,Cinzia Gellera,Antonia Ratti,Franco Taroni,Diane McKenna-Yasek,Peter C Sapp,Vincenzo Silani,Clement E Furlong,Robert H Brown,John E Landers
Source:
Annals of neurology
Axonal transport defects in neurodegenerative diseases
viernes, octubre 16, 2009
Author(s):
Gerardo A Morfini,Matthew Burns,Lester I Binder,Nicholas M Kanaan,Nichole LaPointe,Daryl A Bosco,Robert H Brown,Hannah Brown,Ashutosh Tiwari,Lawrence Hayward,Julia Edgar,Klaus-Armin Nave,James Garberrn,Yuka Atagi,Yuyu Song,Gustavo Pigino,Scott T Brady
Source:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins
martes, junio 16, 2009
Author(s):
Jianmin Gao,Daryl A Bosco,Evan T Powers,Jeffery W Kelly
Source:
Nature structural & molecular biology
Structure and dynamics of pin1 during catalysis by NMR
sábado, febrero 24, 2007
Author(s):
Wladimir Labeikovsky,Elan Z Eisenmesser,Daryl A Bosco,Dorothee Kern
Source:
Journal of molecular biology
Small molecule oxidation products trigger disease-associated protein misfolding
miércoles, septiembre 20, 2006
Author(s):
Jan Bieschke,Qinghai Zhang,Daryl A Bosco,Richard A Lerner,Evan T Powers,Paul Wentworth,Jeffery W Kelly
Source:
Accounts of chemical research
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization
martes, marzo 28, 2006
Author(s):
Daryl A Bosco,Douglas M Fowler,Qinghai Zhang,Jorge Nieva,Evan T Powers,Paul Wentworth,Richard A Lerner,Jeffery W Kelly
Source:
Nature chemical biology
Intrinsic dynamics of an enzyme underlies catalysis
viernes, noviembre 04, 2005
Author(s):
Elan Z Eisenmesser,Oscar Millet,Wladimir Labeikovsky,Dmitry M Korzhnev,Magnus Wolf-Watz,Daryl A Bosco,Jack J Skalicky,Lewis E Kay,Dorothee Kern
Source:
Nature
Catalysis and binding of cyclophilin A with different HIV-1 capsid constructs
miércoles, mayo 19, 2004
Author(s):
Daryl A Bosco,Dorothee Kern
Source:
Biochemistry
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Dr. Daryl A. Bosco, PhD
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News & Articles
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